HIGHLY DIASTEREOSELECTIVE ALKYLATIONS OF CHIRAL AMIDE ENOLATES - NEW ROUTES TO HYDROXYETHYLENE DIPEPTIDE ISOSTERE INHIBITORS OF HIV-1 PROTEASE

被引：134

作者：

ASKIN, D ^{[1
]}

WALLACE, MA ^{[1
]}

VACCA, JP ^{[1
]}

REAMER, RA ^{[1
]}

VOLANTE, RP ^{[1
]}

SHINKAI, I ^{[1
]}

机构：

[1] MERCK SHARP & DOHME LTD,DEPT MED CHEM,W POINT,PA 19486

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1992年 / 57卷 / 10期

关键词：

D O I：

10.1021/jo00036a004

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The nonchelate enforced chiral amide enolates derived from 4-7 react with alkyl iodide and protected alpha-amino epoxide electrophiles to produce the HIV protease inhibitors 10 and 16-19 with high diastereoselectivity.

引用

页码：2771 / 2773

页数：3

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