Solid-phase synthesis of oligo(p-benzamide) foldamers

被引：43

作者：

König, HM ^{[1
]}

Abbel, R ^{[1
]}

Schollmeyer, D ^{[1
]}

Kilbinger, AFM ^{[1
]}

机构：

[1] Johannes Gutenberg Univ Mainz, Inst Organ Chem, D-55099 Mainz, Germany

来源：

ORGANIC LETTERS | 2006年 / 8卷 / 09期

关键词：

D O I：

10.1021/ol0603357

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A coupling protocol has been developed which allows the synthesis of oligo(p-benzamide)s on solid support. Aromatic carboxylic acids are activated in situ with thionyl chloride and used to acylate secondary aromatic amines. N-p-Methoxy benzyl (PMB) as well as N-hexyl protected monomers were investigated. Heterosequences of both monomers were synthesized. Such nanoscale objects are important building blocks for supramolecular chemistry.

引用

页码：1819 / 1822

页数：4

共 33 条

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