Chromatin assembly during DNA replication in somatic cells

被引：54

作者：

Krude, T ^{[1
]}

机构：

[1] Univ Cambridge, Wellcome CRC Inst, Cambridge CB2 1QR, England

来源：

EUROPEAN JOURNAL OF BIOCHEMISTRY | 1999年 / 263卷 / 01期

基金：

英国惠康基金;

关键词：

DNA replication; S phase; nuclei; chromatin; nucleosome; assembly; CAF-1; NAP-1; PCNA; histone;

D O I：

10.1046/j.1432-1327.1999.00508.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Newly replicated DNA is assembled into chromatin through two principle pathways. Firstly, parental nucleosomes segregate to replicated DNA, and are transferred directly to one of the two daughter strands during replication fork passage. Secondly, chromatin assembly factors mediate de-novo assembly of nucleosomes on replicating DNA using newly synthesized and acetylated histone proteins. In somatic cells, chromatin assembly factor 1 (CAF-1) appears to be a key player in assembling new nucleosomes during DNA replication. It provides a molecular connection between newly synthesized histones and components of the DNA replication machinery during the S phase of the cell division cycle.

引用

页码：1 / 5

页数：5

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