Switchable Cell Trapping Using Superparamagnetic Beads

被引：27

作者：

Bryan, Matthew T. ^{[1
]}

Smith, Katherine H. ^{[2
]}

Real, Maria E. ^{[2
]}

Bashir, M. A. ^{[1
]}

Fry, Paul W. ^{[3
]}

Fischer, Peter ^{[4
]}

Im, Mi-Young ^{[4
]}

Schrefl, Thomas ^{[1
,5
]}

Allwood, Dan A. ^{[1
]}

Haycock, John W. ^{[2
]}

机构：

[1] Univ Sheffield, Dept Engn Mat, Sheffield S1 3JD, S Yorkshire, England

[2] Univ Sheffield, Kroto Res Inst, Sheffield S3 7HQ, S Yorkshire, England

[3] Univ Sheffield, Ctr Nanosci & Technol, Sheffield S3 7HQ, S Yorkshire, England

[4] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Ctr Xray Opt, Berkeley, CA 94720 USA

[5] St Poelten Univ Appl Sci, A-3100 St Polten, Austria

来源：

IEEE MAGNETICS LETTERS | 2010年 / 1卷

基金：

英国生物技术与生命科学研究理事会; 英国工程与自然科学研究理事会;

关键词：

Biomagnetics; cell positioning; domain wall; force; magnetic soft X-ray microscopy; superparamagnetic bead;

D O I：

10.1109/LMAG.2010.2046143

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

Ni81Fe19 microwires are investigated as the basis of a switchable template for positioning magnetically labeled neural Schwann cells. Magnetic transmission X-ray microscopy and micromagnetic modeling show that magnetic domain walls can be created or removed in zigzagged structures by an applied magnetic field. Schwann cells containing superparamagnetic beads are trapped by the field emanating from the domain walls. The design allows Schwann cells to be organized on a surface to form a connected network and then released from the surface if required. As aligned Schwann cells can guide nerve regeneration, this technique is of value for developing glial-neuronal coculture models in the future treatment of peripheral nerve injuries.

引用

页数：4

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