Evaluation of tea polyphenols as anti-HIV agents

被引：32

作者：

Hashimoto, F

Kashiwada, Y

Nonaka, G

Nishioka, I

Nohara, T

Cosentino, LM

Lee, KH

机构：

[1] UNIV N CAROLINA,NAT PROD LAB,DIV MED CHEM & NAT PROD,SCH PHARM,CHAPEL HILL,NC 27599

[2] KYUSHU UNIV,FAC PHARMACEUT SCI,FUKUOKA 812,JAPAN

[3] KUMAMOTO UNIV,FAC PHARMACEUT SCI,KUMAMOTO 862,JAPAN

[4] BIOTECH RES LABS INC,ROCKVILLE,MD 20850

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 06期

关键词：

D O I：

10.1016/0960-894X(96)00095-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Thirty-eight tea polyphenols were evaluated for their inhibitory effect against HIV replication in H9 lymphocyte cells. 8-C-Ascorbyl (-)-epigallocatechin (13) and theasinensin-D (32) demonstrated relatively potent anti-HIV activity with EC(50) values of 4 and 8 mu g/mL and therapeutic indexes of 9.5 and 5, respectively.

引用

页码：695 / 700

页数：6

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