3-TETRAHYDROFURAN AND PYRAN URETHANES AS HIGH-AFFINITY P2-LIGANDS FOR HIV-1 PROTEASE INHIBITORS

被引：69

作者：

GHOSH, AK

THOMPSON, WJ

MCKEE, SP

DUONG, TT

LYLE, TA

CHEN, JC

DARKE, PL

ZUGAY, JA

EMINI, EA

SCHLEIF, WA

HUFF, JR

ANDERSON, PS

机构：

[1] MERCK SHARP & DOHME LTD,DEPT VIRUS & CELL BIOL,W POINT,PA 19486

[2] MERCK SHARP & DOHME LTD,DEPT MOLEC BIOL,W POINT,PA 19486

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1993年 / 36卷 / 02期

关键词：

D O I：

10.1021/jm00054a015

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：292 / 294

页数：3

共 18 条

[1] ISOLATION OF A T-LYMPHOTROPIC RETROVIRUS FROM A PATIENT AT RISK FOR ACQUIRED IMMUNE-DEFICIENCY SYNDROME (AIDS) [J].

BARRESINOUSSI, F ;

CHERMANN, JC ;

REY, F ;

NUGEYRE, MT ;

CHAMARET, S ;

GRUEST, J ;

DAUGUET, C ;

AXLERBLIN, C ;

VEZINETBRUN, F ;

ROUZIOUX, C ;

ROZENBAUM, W ;

MONTAGNIER, L .

SCIENCE, 1983, 220 (4599) :868-871

[2] ANTIVIRAL PROPERTIES OF RO 31-8959, AN INHIBITOR OF HUMAN-IMMUNODEFICIENCY-VIRUS (HIV) PROTEINASE [J].

CRAIG, JC ;

DUNCAN, IB ;

HOCKLEY, D ;

GRIEF, C ;

ROBERTS, NA ;

MILLS, JS .

ANTIVIRAL RESEARCH, 1991, 16 (04) :295-305

[3] A STEREOCONTROLLED SYNTHESIS OF HYDROXYETHYLENE DIPEPTIDE ISOSTERES USING NOVEL, CHIRAL AMINOALKYL EPOXIDES AND GAMMA-(AMINOALKYL) GAMMA-LACTONES [J].

EVANS, BE ;

RITTLE, KE ;

HOMNICK, CF ;

SPRINGER, JP ;

HIRSHFIELD, J ;

VEBER, DF .

JOURNAL OF ORGANIC CHEMISTRY, 1985, 50 (23) :4615-4625

[4] ENANTIOSPECIFIC SYNTHESES OF INTERMEDIATES IN THE TOTAL SYNTHESIS OF PSEUDOMONIC ACIDS [J].

FLEET, GWJ ;

GOUGH, MJ .

TETRAHEDRON LETTERS, 1982, 23 (43) :4509-4512

[5] FREQUENT DETECTION AND ISOLATION OF CYTOPATHIC RETROVIRUSES (HTLV-III) FROM PATIENTS WITH AIDS AND AT RISK FOR AIDS [J].

GALLO, RC ;

SALAHUDDIN, SZ ;

POPOVIC, M ;

SHEARER, GM ;

KAPLAN, M ;

HAYNES, BF ;

PALKER, TJ ;

REDFIELD, R ;

OLESKE, J ;

SAFAI, B ;

WHITE, G ;

FOSTER, P ;

MARKHAM, PD .

SCIENCE, 1984, 224 (4648) :500-503

[6] N,N'-DISUCCINIMIDYL CARBONATE - A USEFUL REAGENT FOR ALKOXYCARBONYLATION OF AMINES [J].

GHOSH, AK ;

DUONG, TT ;

MCKEE, SP ;

THOMPSON, WJ .

TETRAHEDRON LETTERS, 1992, 33 (20) :2781-2784

[7] AN EFFICIENT SYNTHESIS OF HYDROXYETHYLENE DIPEPTIDE ISOSTERES - THE CORE UNIT OF POTENT HIV-1 PROTEASE INHIBITORS [J].

GHOSH, AK ;

MCKEE, SP ;

THOMPSON, WJ .

JOURNAL OF ORGANIC CHEMISTRY, 1991, 56 (23) :6500-6503

[8]

GHOSH AK, 1992, J CHEM SOC CHEM COMM, P273, DOI 10.1039/C39920000273

[9] DI(2-PYRIDYL) CARBONATE PROMOTED ALKOXYCARBONYLATION OF AMINES - A CONVENIENT SYNTHESIS OF FUNCTIONALIZED CARBAMATES [J].

GHOSH, AK ;

DUONG, TT ;

MCKEE, SP .

TETRAHEDRON LETTERS, 1991, 32 (34) :4251-4254

[10] AFFINITY PURIFICATION OF THE HIV-1 PROTEASE [J].

HEIMBACH, JC ;

GARSKY, VM ;

MICHELSON, SR ;

DIXON, RAF ;

SIGAL, IS ;

DARKE, PL .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1989, 164 (03) :955-960

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