AN EFFICIENT SYNTHESIS OF HYDROXYETHYLENE DIPEPTIDE ISOSTERES - THE CORE UNIT OF POTENT HIV-1 PROTEASE INHIBITORS

被引：68

作者：

GHOSH, AK

MCKEE, SP

THOMPSON, WJ

机构：

[1] Department of Medicinal Chemistry, Merck Sharp & Dohme Research Laboratories, West Point

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1991年 / 56卷 / 23期

关键词：

D O I：

10.1021/jo00023a009

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and stereocontrolled synthesis of hydroxyethylene dipeptide isosteres 1 from commercially available, optically pure D-mannose is described. This synthesis represents a practical and enantioselective entry to a range of other dipeptide isosteres, which are not limited to amino acid derived substituents.

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页码：6500 / 6503

页数：4

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