CANCER Drug for an 'undruggable' protein

被引：43

作者：

Baker, Nicole M. ^{[1
]}

Der, Channing J. ^{[1
]}

机构：

[1] Univ N Carolina, Lineberger Comprehens Canc Ctr, Dept Pharmacol, Chapel Hill, NC 27599 USA

来源：

NATURE | 2013年 / 497卷 / 7451期

关键词：

RAS; TRANSPORT;

D O I：

10.1038/nature12248

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Scientists have long aimed to develop drugs against the cancer-associated protein KRAS, but without success. An approach that targets the oncoprotein's cellular localization reignites lost enthusiasm. See Letter p.638

引用

页码：577 / 578

页数：2

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