Organochlorine compounds in human brain

被引：32

作者：

Corrigan, FM

French, M

Murray, L

机构：

[1] INST TERR ECOL,HUNTINGDON,CAMBS,ENGLAND

[2] VALE LEVEN DIST GEN HOSP,ALEXANDRIA,DUNBARTON,SCOTLAND

来源：

HUMAN & EXPERIMENTAL TOXICOLOGY | 1996年 / 15卷 / 03期

关键词：

Parkinson's Disease; polychlorinated biphenyls; pp'DDE-Dieldrin;

D O I：

10.1177/096032719601500314

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Having observed polychlorinated biphenyls (PCBs) in brain tissue obtained post mortem from two men we have carried out a study of organochlorine compounds in frontal cortex from patients with Parkinson's disease (PD) and from controls. No PCBs were found in any of those samples. There was no difference in the concentration of the DDT metabolite pp'-DDE in the PD brain samples. Dieldrin (HEOD) was significantly decreased in PD brain when analysed by lipid weight. While these findings would not support the hypothesis that PCBs may contribute to the development of Parkinson's disease in humans it remains possible that they may cause damage to the basal ganglia before being displaced from brain tissue.

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收藏

页码：262 / 264

页数：3

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