Synthesis and evaluation of aminoglycosides as inhibitors for rev binding to rev responsive element

被引：1

作者：

Adachi, H

Takahashi, Y

Kyo, M

Sato, T

Nishimura, Y

机构：

[1] Microbial Chem Res Ctr, Shinagawa Ku, Tokyo 1410021, Japan

[2] Tokyo Univ Sci, Shinjuku Ku, Tokyo 1628601, Japan

[3] Toyobo Co Ltd, Fukui 9140047, Japan

来源：

LETTERS IN DRUG DESIGN & DISCOVERY | 2006年 / 3卷 / 02期

关键词：

aminoglycoside; surface plasmon resonance imaging; RNA recognition;

D O I：

10.2174/157018006775789694

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

Interactions of gamma-amino or guanidino-alpha-hydroxybutyryl-aminoglycosides with an essential sequence of Rev responsive element (RRE) in HIV-1 mRNA were evaluated using surface plasmon resonance imaging. Aminoglycosides were proved to bind nonspecifically to RRE.

引用

收藏

页码：71 / 75

页数：5

相关论文

共 34 条

[1]

Synthesis and anti-HIV activity of guanidinoglycosides [J].

Baker, TJ ;

Luedtke, NW ;

Tor, Y ;

Goodman, M .

JOURNAL OF ORGANIC CHEMISTRY, 2000, 65 (26) :9054-9058

[2]

IDENTIFICATION OF A NOVEL CELLULAR COFACTOR FOR THE REV/REX CLASS OF RETROVIRAL REGULATORY PROTEINS [J].

BOGERD, HP ;

FRIDELL, RA ;

MADORE, S ;

CULLEN, BR .

CELL, 1995, 82 (03) :485-494

[3]

Surface plasmon resonance imaging measurements of ultrathin organic films [J].

Brockman, JM ;

Nelson, BP ;

Corn, RM .

ANNUAL REVIEW OF PHYSICAL CHEMISTRY, 2000, 51 :41-63

[4]

Anti-human immunodeficiency virus activity of novel aminoglycoside-arginine conjugates at early stages of infection [J].

Cabrera, C ;

Gutiérrez, A ;

Blanco, J ;

Barretina, J ;

Litovchick, A ;

Lapidot, A ;

Evdokimov, AG ;

Clotet, B ;

Esté, JA .

AIDS RESEARCH AND HUMAN RETROVIRUSES, 2000, 16 (07) :627-634

[5]

SPECIFIC BINDING OF HIV-1 RECOMBINANT REV PROTEIN TO THE REV-RESPONSIVE ELEMENT INVITRO [J].

DALY, TJ ;

COOK, KS ;

GRAY, GS ;

MAIONE, TE ;

RUSCHE, JR .

NATURE, 1989, 342 (6251) :816-819

[6]

A cationic cyclophane that forms a base-pair open complex with RNA duplexes [J].

FernandezSaiz, M ;

Schneider, HJ ;

Sartorius, J ;

Wilson, WD .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1996, 118 (20) :4739-4745

[7]

THE HIV-1 REV ACTIVATION DOMAIN IS A NUCLEAR EXPORT SIGNAL THAT ACCESSES AN EXPORT PATHWAY USED BY SPECIFIC CELLULAR RNAS [J].

FISCHER, U ;

HUBER, J ;

BOELENS, WC ;

MATTAJ, IW ;

LUHRMANN, R .

CELL, 1995, 82 (03) :475-483

[8]

FISCHER U, 1994, EMBO J, V13, P4015

[9]

Aminoglycoside antibiotics, neamine and its derivatives as potent inhibitors for the RNA-protein interactions derived from HIV-1 activators [J].

Hamasaki, K ;

Ueno, A .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2001, 11 (04) :591-594

[10]

Direct observation of aminoglycoside-RNA interactions by surface plasmon resonance [J].

Hendrix, M ;

Priestley, ES ;

Joyce, GF ;

Wong, CH .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1997, 119 (16) :3641-3648

← 1 2 3 4 →