Aminoglycoside antibiotics, neamine and its derivatives as potent inhibitors for the RNA-protein interactions derived from HIV-1 activators

被引：43

作者：

Hamasaki, K ^{[1
]}

Ueno, A ^{[1
]}

机构：

[1] Tokyo Inst Technol, Grad Sch Biosci & Biotechnol, Dept Bioengn, Yokohama, Kanagawa 2268501, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 04期

关键词：

D O I：

10.1016/S0960-894X(01)00005-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Neamine derivatives which have an arginine (RN), a pyrene (PCN) and both pyrene and arginine (PRN) have been prepared and their binding toward the RNA fragments derived from HIV-1 activator region, TAR and RRE RNA were examined. Among them, PRN bound either TAR RNA or RRE RNA with equivalent binding affinities as Tat and Rev peptide, respectively. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：591 / 594

页数：4

共 17 条

[1] alpha helix-RNA major groove recognition in an HIV-1 Rev peptide RRE RNA complex [J].

Battiste, JL ;

Mao, HY ;

Rao, NS ;

Tan, RY ;

Muhandiram, DR ;

Kay, LE ;

Frankel, AD ;

Williamson, JR .

SCIENCE, 1996, 273 (5281) :1547-1551

[2] Structural rearrangements of HIV-1 Tat-responsive RNA upon binding of neomycin B [J].

Faber, C ;

Sticht, H ;

Schweimer, K ;

Rösch, P .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (27) :20660-20666

[3]

FOURMY D, 1996, SCIENCE, V274, P1307

[4] Minimal RNA constructs that specifically bind aminoglycoside antibiotics with high affinities [J].

Hamasaki, K ;

Killian, J ;

Cho, JY ;

Rando, RR .

BIOCHEMISTRY, 1998, 37 (02) :656-663

[5] An aminoglycoside antibiotic, neamine, and its aromatic ring-substituted derivatives as potential inhibitors for HIV-I RRE-Rev [J].

Hamasaki, K ;

Woo, MC ;

Ueno, A .

TETRAHEDRON LETTERS, 2000, 41 (43) :8327-8332

[6] Direct observation of aminoglycoside-RNA interactions by surface plasmon resonance [J].

Hendrix, M ;

Priestley, ES ;

Joyce, GF ;

Wong, CH .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1997, 119 (16) :3641-3648

[7] A structural model for the HIV-1 Rev-RRE complex deduced from altered-specificity rev variants isolated by a rapid genetic strategy [J].

Jain, C ;

Belasco, JG .

CELL, 1996, 87 (01) :115-125

[8] Mechanism of neomycin and Rev peptide binding to the Rev responsive element of HIV-1 as determined by fluorescence and NMR spectroscopy [J].

Lacourciere, KA ;

Stivers, JT ;

Marino, JP .

BIOCHEMISTRY, 2000, 39 (19) :5630-5641

[9] A high-throughput screening utilizing intramolecular fluorescence resonance energy transfer for the discovery of the molecules that bind HIV-1 TAR RNA specifically [J].

Matsumoto, C ;

Hamasaki, K ;

Mihara, H ;

Ueno, A .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2000, 10 (16) :1857-1861

[10] Modulation of RNA function by aminoglycoside antibiotics [J].

Schroeder, R ;

Waldsich, C ;

Wank, H .

EMBO JOURNAL, 2000, 19 (01) :1-9

← 1 2 →