A practical enzymatic procedure for the resolution of N-substituted 2-azabicyclo[2.2.1]hept-5-en-3-one

被引：35

作者：

Mahmoudian, M ^{[1
]}

Lowdon, A ^{[1
]}

Jones, M ^{[1
]}

Dawson, M ^{[1
]}

Wallis, C ^{[1
]}

机构：

[1] Glaxo Wellcome Res & Dev Ltd, Med Res Ctr, Stevenage SG1 2NY, Herts, England

来源：

TETRAHEDRON-ASYMMETRY | 1999年 / 10卷 / 06期

关键词：

D O I：

10.1016/S0957-4166(99)00091-9

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A simple and efficient process for the enantioselective resolution of N-substituted 2-azabicyclo[2.2.1]hept-5-en-3-one has been developed using commercially available hydrolytic enzymes. This offers a practical approach for the preparation of enantiomerically pure N-substituted gamma-lactams. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：1201 / 1206

页数：6

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