Viral diversity and dynamics in an infant gut

被引：270

作者：

Breitbart, Mya ^{[1
]}

Haynes, Matthew ^{[2
]}

Kelley, Scott ^{[2
]}

Angly, Florent ^{[2
,3
]}

Edwards, Robert A. ^{[4
,5
]}

Felts, Ben ^{[3
]}

Mahaffy, Joseph M. ^{[3
]}

Mueller, Jennifer ^{[2
,3
]}

Nulton, James ^{[3
]}

Rayhawk, Steve ^{[2
,3
]}

Rodriguez-Brito, Beltran ^{[2
,3
]}

Salamon, Peter ^{[3
]}

Rohwer, Forest ^{[2
]}

机构：

[1] Univ S Florida, Coll Marine Sci, St Petersburg, FL 33701 USA

[2] San Diego State Univ, Dept Biol, San Diego, CA 92182 USA

[3] San Diego State Univ, Dept Math Sci, San Diego, CA 92182 USA

[4] San Diego State Univ, Dept Comp Sci, San Diego, CA 92182 USA

[5] Argonne Natl Lab, Div Math & Comp Sci, Argonne, IL 60439 USA

来源：

RESEARCH IN MICROBIOLOGY | 2008年 / 159卷 / 05期

关键词：

infant; feces; virus; phage; metagenomics; microarray; gut;

D O I：

10.1016/j.resmic.2008.04.006

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Metagenomic sequencing of DNA viruses from the feces of a healthy week-old infant revealed a viral community with extremely low diversity. The identifiable sequences were dominated by phages, which likely influence the diversity and abundance of co-occurring microbes. The most abundant fecal viral sequences did not originate from breast milk or formula, suggesting a non-dietary initial source of viruses. Certain sequences were stable in the infant's gut over the first 3 months of life, but microarray experiments demonstrated that the overall viral community composition changed dramatically between I and 2 weeks of age. (C) 2008 Elsevier Masson SAS. All rights reserved.

引用

页码：367 / 373

页数：7

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