Adult-specific functions of animal microRNAs

被引：310

作者：

Sun, Kailiang ^{[1
]}

Lai, Eric C. ^{[1
]}

机构：

[1] Sloan Kettering Inst, Dept Dev Biol, New York, NY 10065 USA

来源：

NATURE REVIEWS GENETICS | 2013年 / 14卷 / 08期

基金：

美国国家卫生研究院;

关键词：

UTR SEQUENCE MOTIF; CELL-PROLIFERATION; TUMOR-SUPPRESSOR; IN-VIVO; STEM-CELLS; SMALL RNAS; POSTTRANSCRIPTIONAL REGULATION; MESENCHYMAL TRANSITION; EPIGENETIC REGULATION; TARGETED DELETION;

D O I：

10.1038/nrg3471

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

MicroRNAs (miRNAs) are similar to 22 nt RNAs that coordinate vast regulatory networks in animals and thereby influence myriad processes. This Review examines evidence that miRNAs have continuous roles in adults in ways that are separable from developmental control. Adult-specific activities for miRNAs have been described in various stem cell populations, in the context of neural function and cardiovascular biology, in metabolism and ageing, and during cancer. In addition to reviewing recent results, we also discuss methods for studying miRNA activities specifically in adults and evaluate their relative strengths and weaknesses. A fuller understanding of continuous functions of miRNAs in adults has bearing on efforts and opportunities to manipulate miRNAs for therapeutic purposes.

引用

页码：535 / 548

页数：14

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