Epigenetic codes for heterochromatin formation and silencing: Rounding up the usual suspects

被引：677

作者：

Richards, EJ ^{[1
]}

Elgin, SCR ^{[1
]}

机构：

[1] Washington Univ, Dept Biol, St Louis, MO 63130 USA

来源：

CELL | 2002年 / 108卷 / 04期

关键词：

D O I：

10.1016/S0092-8674(02)00644-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent results from diverse organisms point to a self-reinforcing network of interactions among the three best-characterized covalent modifications that mark heterochromatin: histone hypoacetylation, histone H3-Lys9 methylation, and cytosine methylation. These modification systems suggest a mechanistic basis for spreading of heterochromatin over large domains and for stable epigenetic inheritance of the silent state. All three modifications used in packaging heterochromatin are also used in stable silencing of euchromatic genes.

引用

页码：489 / 500

页数：12

共 103 条

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