A computerized system for the simultaneous monitoring of place conditioning and locomotor activity in rats

被引：22

作者：

Brockwell, NT ^{[1
]}

Ferguson, DS ^{[1
]}

Beninger, RJ ^{[1
]}

机构：

[1] QUEENS UNIV,DEPT PSYCHOL,KINGSTON,ON K7L 3N6,CANADA

来源：

JOURNAL OF NEUROSCIENCE METHODS | 1996年 / 64卷 / 02期

基金：

加拿大自然科学与工程研究理事会;

关键词：

place conditioning; conditioned place preference; locomotor activity; experiment controller; (+)- amphetamine;

D O I：

10.1016/0165-0270(95)00128-X

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Place conditioning is one of the most popular behavioral methods for assessing the rewarding properties of various substances. Many substances that are rewarding also influence motor activity. This report describes a computerized system designed to simultaneously monitor both place conditioning and locomotor activity. The system consists of 4 independent conditioning boxes, each equipped with 6 pairs of photosensors connected to an Experiment Controller, an electronic board containing a microprocessor, a programable timer, and 16 K of RAM used to store both instructions and data. The effects of the stimulant (+) - amphetamine were assessed using this system and found to produce a place preference comparable to that obtained from a previously utilized mechanical timer system. The computerized system also demonstrated that amphetamine increased unconditioned activity. There are a number of advantages and broader applications of the new methodology.

引用

页码：227 / 232

页数：6

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