Computer-assisted structural elucidation.: Alkaloids with a novel diaza-adamantane skeleton from the seeds of Acosmium panamense (Fabaceae).

被引:36
作者
Nuzillard, JM
Connolly, JD
Delaude, C
Richard, B
Zèches-Hanrot, M
Le Men-Olivier, L
机构
[1] CPCBAI, UPRESA 6013, Lab Pharmacognosie, F-51097 Reims 2, France
[2] Univ Glasgow, Dept Chem, Glasgow G12 8QQ, Lanark, Scotland
[3] Univ Liege, Inst Chim B6, Ctr Rech Phytochim, B-4000 Liege 1, Belgium
关键词
D O I
10.1016/S0040-4020(99)00661-4
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Three alkaloids, acosmine 1, acosmine acetate 2 and panacosmine 3 with a novel diazaadamantane skeleton and an unusual N-acetyl enamine moiety, have been isolated from the seeds of Acosmium panamense (Benth.). The structures were assembled on the basis or COSY, HMQC and HMBC data with the assistance of the LSD structure elucidation program. Proton-nitrogen HMBC experiments support the proposed structures. Other isolated compounds include 4 alpha-angeloyloxy-3 beta-hydroxy-13 beta-methoxylupanine 4, a new compound and the known alkaloids lupanine and multiflorine. (C) 1999 Elsevier Science Ltd. All rights reserved.
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收藏
页码:11511 / 11518
页数:8
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