Role of tumor necrosis factor alpha in asthma

被引：57

作者：

Babu, KS ^{[1
]}

Davies, DE ^{[1
]}

Holgate, ST ^{[1
]}

机构：

[1] Southampton Gen Hosp, Southampton SO16 6YD, Hants, England

来源：

IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA | 2004年 / 24卷 / 04期

关键词：

D O I：

10.1016/j.iac.2004.06.010

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Asthma is a heterogeneous disease in which various cytokines orchestrate airway inflammation. Tumor necrosis alpha (TNF-alpha) is a proinflammatory cytokine that has been implicated in the modulation of inflammation in various diseases, including asthma. Although TNF-alpha blocking strategies have been an effective therapeutic modality in diseases such as rheumatoid arthritis, their role in asthma and the effects of the blockade in asthma is poorly understood. This article examines the role of TNF-alpha in asthma and the effects of blocking TNF-alpha as a possible therapeutic option in patients with severe corticosteroid-dependent asthma.

引用

页码：583 / +

页数：17

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