Expression of Galectin-3 in Pancreatic Ductal Adenocarcinoma

被引：17

作者：

Gaida, Matthias M. ^{[1
]}

Bach, Sylvia T. ^{[1
,2
]}

Guenther, Frank ^{[2
]}

Baseras, Billur ^{[2
]}

Tschaharganeh, Darjus F. ^{[1
]}

Welsch, Thilo ^{[3
]}

Felix, Klaus ^{[3
]}

Bergmann, Frank ^{[1
]}

Haensch, Gertrud M. ^{[2
]}

Wente, Moritz N. ^{[3
]}

机构：

[1] Heidelberg Univ, Inst Pathol, D-69120 Heidelberg, Germany

[2] Heidelberg Univ, Inst Immunol, D-69120 Heidelberg, Germany

[3] Heidelberg Univ, Dept Surg, D-69120 Heidelberg, Germany

来源：

PATHOLOGY & ONCOLOGY RESEARCH | 2012年 / 18卷 / 02期

关键词：

Pancreatic cancer; Galectins; Galectin-3; Expression; CLINICAL-SIGNIFICANCE; CANCER; TUMOR; PROGRESSION; PATTERN; GROWTH; MARKER;

D O I：

10.1007/s12253-011-9444-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Galectin-3 influences neoangiogenesis, tumor cell adhesion, and tumor-immune-escape mechanisms. Hence, the expression of galectin-3 in pancreatic ductal adenocarcinoma (PDAC) was evaluated. Galectin-3 expression in PDAC cell lines was proven by the presence of intracellular protein and by release into the supernatant. Furthermore, galectin-3 was found in the majority of human tissue samples. Serum concentrations of galectin-3 in PDAC patients did not differ significantly from healthy donors and did not correlate with established tumor markers. In conclusion, galectin-3 is expressed in PDAC tissues suggesting a role in tumor development; however, no relationship between expression and clinical findings could be established.

引用

页码：299 / 307

页数：9

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