Therapeutic nanoreactors:: Combining chemistry and biology in a novel triblock copolymer drug delivery system

被引：177

作者：

Ranquin, A

Versées, W

Meier, W

Steyaert, J

Van Gelder, P

机构：

[1] Vrije Univ Brussels, Dept Mol & Cellular Interact, B-1050 Brussels, Belgium

[2] Vrije Univ Brussels VIB, B-1050 Brussels, Belgium

[3] Univ Basel, Dept Chem, CH-4056 Basel, Switzerland

来源：

NANO LETTERS | 2005年 / 5卷 / 11期

关键词：

D O I：

10.1021/nl051523d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Triblock copolymeric nanoreactors are introduced as an alternative for liposomes as encapsulating carrier for prodrug activating enzymes. Inosine-adenosine-guanosine preferring nucleoside hydrolase of Trypanosoma vivax, a potential prodrug activating enzyme, was encapsulated in nanometer-sized vesicles constructed of poly(2-methyloxazoline)-block-poly(dimethylsiloxane)-block-(2-methyloxazoline) triblock copolymers. The nanoreactor is functionalized by incorporation of bacterial porins, OmpF or Tsx, in the reactor wall. Efficient cleavage of three natural substrates and one prodrug, 2-fluoroadenosine, by the nanoreactors was demonstrated.

引用

页码：2220 / 2224

页数：5

共 28 条

[11] Adenine deoxynucleotides fludarabine and cladribine induce apoptosis in a CD95/Fas receptor, FADD and caspase-8-independent manner by activation of the mitochondrial cell death pathway [J].