Genetics of Parkinson disease: paradigm shifts and future prospects

被引:537
作者
Farrer, MJ [1 ]
机构
[1] Morris K Udall Parkinsons Dis Res Ctr, Dept Neurosci, Mayo Clin, Jacksonville, FL 32224 USA
关键词
D O I
10.1038/nrg1831
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Parkinson disease is a complex, multifactorial neurodegenerative disease. Although a heritable basis was originally thought unlikely, recent studies have implicated several genes in its pathogenesis, and molecular findings now allow accurate diagnosis and challenge past criteria for defining Parkinson disease. Most importantly, genetic insights provide the rationale for new strategies for prevention or therapy, and have led to animal models of disease in which these strategies can be tested. Neuroprotective therapies can now be designed to slow or halt disease progression in affected subjects and asymptomatic carriers.
引用
收藏
页码:306 / 318
页数:13
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