Natural functions of bacterial multidrug transporters

被引:86
作者
Neyfakh, AA
机构
[1] Ctr. for Pharmaceutical Biotech., M/C 870, University of Illinois, Chicago, IL 60607
关键词
D O I
10.1016/S0966-842X(97)01064-0
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Bacteria express several multidrug transporters that recognize structurally dissimilar toxic molecules and expel them from cells. These transporters may have evolved to protect bacteria from diverse environmental toxins or to transport specific physiological compounds with the ability to expel drugs being only a fortuitous side effect.
引用
收藏
页码:309 / 313
页数:5
相关论文
共 41 条
[1]   2 HIGHLY SIMILAR MULTIDRUG TRANSPORTERS OF BACILLUS-SUBTILIS WHOSE EXPRESSION IS DIFFERENTIALLY REGULATED [J].
AHMED, M ;
LYASS, L ;
MARKHAM, PN ;
TAYLOR, SS ;
VAZQUEZLASLOP, N ;
NEYFAKH, AA .
JOURNAL OF BACTERIOLOGY, 1995, 177 (14) :3904-3910
[2]  
AHMED M, 1994, J BIOL CHEM, V269, P28506
[3]   CLONING AND SEQUENCE-ANALYSIS OF AN ESCHERICHIA-COLI GENE CONFERRING BICYCLOMYCIN RESISTANCE [J].
BENTLEY, J ;
HYATT, LS ;
AINLEY, K ;
PARISH, JH ;
HERBERT, RB ;
WHITE, GR .
GENE, 1993, 127 (01) :117-120
[4]   THE LACTOCOCCAL LMRP GENE ENCODES A PROTON MOTIVE FORCE-DEPENDENT DRUG TRANSPORTER [J].
BOLHUIS, H ;
POELARENDS, G ;
VANVEEN, HW ;
POOLMAN, B ;
DRIESSEN, AJM ;
KONINGS, WN .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (44) :26092-26098
[5]   Substrate specificity of the Escherichia coli 4-aminobutyrate carrier encoded by gabP - Uptake and counterflow of structurally diverse molecules [J].
Brechtel, CE ;
Hu, LY ;
King, SC .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (02) :783-788
[6]   GENETIC AND FUNCTIONAL-ANALYSIS OF THE MULTIPLE ANTIBIOTIC-RESISTANCE (MAR) LOCUS IN ESCHERICHIA-COLI [J].
COHEN, SP ;
HACHLER, H ;
LEVY, SB .
JOURNAL OF BACTERIOLOGY, 1993, 175 (05) :1484-1492
[7]  
COHEN SP, 1988, J BACTERIOL, V170, pS416
[8]   MdfA, an Escherichia coli multidrug resistance protein with an extraordinarily broad spectrum of drug recognition [J].
Edgar, R ;
Bibi, E .
JOURNAL OF BACTERIOLOGY, 1997, 179 (07) :2274-2280
[9]   BIOCHEMISTRY OF MULTIDRUG-RESISTANCE MEDIATED BY THE MULTIDRUG TRANSPORTER [J].
GOTTESMAN, MM ;
PASTAN, I .
ANNUAL REVIEW OF BIOCHEMISTRY, 1993, 62 :385-427
[10]   RESISTANCE OF NEISSERIA-GONORRHOEAE TO ANTIMICROBIAL HYDROPHOBIC AGENTS IS MODULATED BY THE MTRRCDE EFFLUX SYSTEM [J].
HAGMAN, KE ;
PAN, WB ;
SPRATT, BG ;
BALTHAZAR, JT ;
JUDD, RC ;
SHAFER, WM .
MICROBIOLOGY-SGM, 1995, 141 :611-622