Triazole-linked analogue of deoxyribonucleic acid (TLDNA):: Design, synthesis, and double-strand formation with natural DNA

被引：158

作者：

Isobe, Hiroyuki ^{[1
]}

Fujino, Tomoko ^{[1
]}

Yamazaki, Naomi ^{[1
]}

Guillot-Nieckowski, Marine ^{[2
]}

Nakamura, Eiichi ^{[2
]}

机构：

[1] Tohoku Univ, Dept Chem, Aoba Ku, Sendai, Miyagi 9808578, Japan

[2] Univ Tokyo, Dept Chem, Bunkyo Ku, Tokyo 1130033, Japan

来源：

ORGANIC LETTERS | 2008年 / 10卷 / 17期

关键词：

D O I：

10.1021/ol801230k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new triazole-linked analogue of DNA ((TL)DNA) has been designed and synthesized using click chemistry. The chain elongation reaction using copper-catalyzed Huisgen cycloaddition was successful and gave the artificial oligonucleotide that formed a stable double strand with the complementary strand of natural DNA.

引用

页码：3729 / 3732

页数：4

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