Autoimmune diseases and infections as risk factors for schizophrenia

被引：133

作者：

Benros, Michael E. ^{[1
,2
]}

Mortensen, Preben B. ^{[1
]}

Eaton, William W. ^{[3
]}

机构：

[1] Aarhus Univ, Natl Ctr Register Based Res, iPSYCH, Taasingegade 1, DK-8000 Aarhus C, Denmark

[2] Univ Copenhagen, Mental Hlth Ctr Copenhagen, Copenhagen, Denmark

[3] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Mental Hlth, Baltimore, MD USA

来源：

NEUROIMMUNOMODULATION IN HEALTH AND DISEASE II | 2012年 / 1262卷

关键词：

schizophrenia; autoimmune disease; infection; inflammation; epidemiology; CEREBROSPINAL-FLUID; PSYCHIATRIC MANIFESTATIONS; MULTIPLE-SCLEROSIS; MOLECULAR MIMICRY; BIPOLAR DISORDER; CELIAC-DISEASE; HERPES-SIMPLEX; IMMUNE-SYSTEM; ANTIBODIES; CHILDHOOD;

D O I：

10.1111/j.1749-6632.2012.06638.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immunological hypotheses have become increasingly prominent when studying the etiology of schizophrenia. Autoimmune diseases, and especially the number of infections requiring hospitalization, have been identified as significant risk factors for schizophrenia in a dose-response relationship, which seem compatible with an immunological hypothesis for subgroups of patients with schizophrenia. Inflammation and infections may affect the brain through many different pathways that are not necessarily mutually exclusive and can possibly increase the risk of schizophrenia in vulnerable individuals. However, the findings could also be an epiphenomenon and not causal, due to, for instance, common genetic vulnerability, which could be supported by the observations of an increased prevalence of autoimmune diseases and infections in parents of patients with schizophrenia. Nevertheless, autoimmune diseases and infections should be considered in the treatment of individuals with schizophrenia symptoms, and further research is needed of the immune system's possible contributing pathogenic factors in the etiology of schizophrenia.

引用

页码：56 / 66

页数：11

共 100 条

[11] Molecular mimicry in infectious encephalitis and neuritis: Binding of antibodies against infectious agents on Western blots of human nervous tissue [J].