WHO classification 2008 of myeloproliferative neoplasms: a workshop learning effect - the Danish experience

被引：4

作者：

Madelung, Ann B. ^{[1
]}

Bondo, Henrik ^{[1
]}

Stamp, Inger ^{[1
]}

Lovgreen, Preben ^{[2
]}

Nielsen, Signe L. ^{[3
]}

Falensteen, Anne ^{[3
]}

Knudsen, Helle ^{[3
]}

Svendsen, Kira D. ^{[4
]}

Lange, Theis ^{[4
]}

Ralfkiaer, Elisabeth ^{[5
]}

Nielsen, Karsten ^{[1
]}

Hasselbalch, Hans ^{[6
]}

Thiele, Juergen ^{[7
]}

机构：

[1] Naestved & Slagelse Hosp, Dept Pathol, DK-4700 Naestved, Denmark

[2] Roskilde & Koge Hosp, Dept Pathol, Roskilde, Denmark

[3] Herlev Hosp, Dept Pathol, DK-2730 Herlev, Denmark

[4] Univ Copenhagen, Dept Biostat, Copenhagen, Denmark

[5] Copenhagen Univ Hosp, Dept Pathol, Copenhagen, Denmark

[6] Roskilde & Koge Hosp, Dept Haematol, Roskilde, Denmark

[7] Univ Cologne, Inst Pathol, Cologne, Germany

来源：

APMIS | 2015年 / 123卷 / 09期

关键词：

Learning effect; interobserver agreement; myeloproliferative neoplasms; workshop; multiheaded microscope; WORLD-HEALTH-ORGANIZATION; BONE-MARROW FIBROSIS; ESSENTIAL THROMBOCYTHEMIA; PRIMARY MYELOFIBROSIS; EUROPEAN CONSENSUS; DIAGNOSIS; RUXOLITINIB; PATHOLOGY; SURVIVAL; CRITERIA;

D O I：

10.1111/apm.12417

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We examined the learning effect of a workshop for Danish hematopathologists led by an international expert regarding histological subtyping of myeloproliferative neoplasms (MPN). Six hematopathologists evaluated 43 bone marrow (BM) biopsies according to the WHO description (2008), blinded to clinical data. All panelists then participated in the workshop. The case biopsies - mixed with 251 other MPN BM biopsies - were reviewed again. Consensus regarding the histological subtype was significantly improved; from 49% to 72% (Fleiss kappa value 0.302 pre-workshop, 0.474 post-workshop; p=0.004). There was no significant effect on the isolated morphological characteristics. Agreement between cases with histological consensus and clinical diagnosis was 86% without significant change during workshop sessions. Our study demonstrates that experienced hematopathologists can significantly improve their diagnostic ability by a workshop led by an international expert; not by improving the evaluation of individual histological parameters but by weighting these in their conclusive diagnosis.

引用

页码：787 / 792

页数：6

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