Asymmetric synthesis of both enantiomers of two acyclic nucleoside analogues related to d4T and acyclovir

被引：13

作者：

Ewing, DF

Glaçon, V

Mackenzie, G

Len, C

机构：

[1] Univ Picardie Jules Verne, Lab Glucides, F-80039 Amiens, France

[2] Univ Hull, Dept Chem, Ctr Organ & Biol Chem, Kingston Upon Hull HU6 7RX, N Humberside, England

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 06期

关键词：

acyclic nucleosides; d4T acyclovir; asymmetric dihydroxylation;

D O I：

10.1016/S0040-4039(01)02298-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The enantiomers of 1-{[(2-hydroxy-1-phenyl)ethoxy]methyl}thymine and 9-{[(2-hydroxy-1-phenyl)ethoxy]methyl}guanine have been obtained in high yield in live steps from (R)- and (S)-1-phenylethan-1,2-diol. These chiral compounds are acyclic nucleoside analogues of d4T and acyclovir, respectively. (C) 2002 Elsevier Science Ltd. All rights reserved.

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收藏

页码：989 / 991

页数：3

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