Xanthoquinodins from the Endolichenic Fungal Strain Chaetomium elatum

被引：50

作者：

Chen, Guo-Dong ^{[1
,4
]}

Chen, Ying ^{[1
]}

Gao, Hao ^{[1
]}

Shen, Li-Qing ^{[1
]}

Wu, Yang ^{[1
]}

Li, Xiao-Xia ^{[1
]}

Li, Yan ^{[2
]}

Guo, Liang-Dong ^{[3
]}

Cen, Ying-Zhou ^{[4
]}

Yao, Xin-Sheng ^{[1
]}

机构：

[1] Jinan Univ, Coll Pharm, Inst Tradit Chinese Med & Nat Prod, Guangzhou 510632, Guangdong, Peoples R China

[2] Chinese Acad Sci, State Key Lab Photochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650204, Peoples R China

[3] Chinese Acad Sci, Inst Microbiol, State Key Lab Mycol, Beijing 100190, Peoples R China

[4] Jinan Univ, Dept Chem, Guangzhou 510632, Guangdong, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2013年 / 76卷 / 04期

关键词：

CERCOSPORA-BETICOLA TOXINS; HUMICOLA SP; PROLIFERATION; ASSAY;

D O I：

10.1021/np400041y

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Five new xanthoquinodins, A4-A6 (1-3), B4 (4), and B5 (5), were isolated from the crude extract of the endolichenic fungal strain Chaetomium elatum (No. 63-10-3-1), along with three known xanthoquinodins, A1-A3 (6-8). Their structures were determined by detailed spectroscopic analysis and comparison of the NMR data with those of the closely related compounds previously reported. The absolute configuration of 1 was established by X-ray crystallographic analysis and ECD calculation. The cytotoxic activity of all compounds was tested against HL-60, SMMC-7721, A-549, MCF-7, and SW480 human cancer cell lines.

引用

页码：702 / 709

页数：8

共 17 条

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[2]

Cytotoxic xanthone-anthraquinone heterodimers from an unidentified fungus of the order Hypocreales (MSX 17022) [J].