Expanding roles for miRNAs and siRNAs in cell regulation

被引：69

作者：

Nakahara, K ^{[1
]}

Carthew, RW ^{[1
]}

机构：

[1] Northwestern Univ, Dept Biochem Mol Biol & Cell Biol, Evanston, IL 60208 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2004年 / 16卷 / 02期

关键词：

D O I：

10.1016/j.ceb.2004.02.006

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The role of small RNAs as key regulators of mRNA turnover and translation has been well established. Recent advances indicate that the small RNAs termed microRNAs play important roles in cell proliferation, apoptosis and differentiation. Moreover, the microRNA mechanism is an efficient means to regulate production of a diverse range of proteins. As new microRNAs and their mRNA targets rapidly emerge, it is becoming apparent that RNA-based regulation of mRNAs may rival ubiquitination as a mechanism to control protein levels.

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收藏

页码：127 / 133

页数：7

相关论文

共 59 条

[1] The Caenorhabditis elegans hunchback-like gene lin-57/hbl-1 controls developmental time and is regulated by microRNAs [J].

Abrahante, JE ;

Daul, AL ;

Li, M ;

Volk, ML ;

Tennessen, JM ;

Miller, EA ;

Rougvie, AE .

DEVELOPMENTAL CELL, 2003, 4 (05) :625-637

[2] MicroRNAs and other tiny endogenous RNAs in C-elegans [J].

Ambros, V ;

Lee, RC ;

Lavanway, A ;

Williams, PT ;

Jewell, D .

CURRENT BIOLOGY, 2003, 13 (10) :807-818

[3] The small RNA profile during Drosophila melanogaster development [J].

Aravin, AA ;

Lagos-Quintana, M ;

Yalcin, A ;

Zavolan, M ;

Marks, D ;

Snyder, B ;

Gaasterland, T ;

Meyer, J ;

Tuschl, T .

DEVELOPMENTAL CELL, 2003, 5 (02) :337-350

[4] Double-stranded RNA-mediated silencing of genomic tandem repeats and transposable elements in the D-melanogaster germline [J].

Aravin, AA ;

Naumova, NM ;

Tulin, AV ;

Vagin, VV ;

Rozovsky, YM ;

Gvozdev, VA .

CURRENT BIOLOGY, 2001, 11 (13) :1017-1027

[5] Regulation of flowering time and floral organ identity by a microRNA and its APETALA2-like target genes [J].

Aukerman, MJ ;

Sakai, H .

PLANT CELL, 2003, 15 (11) :2730-2741

[6] Dicer is essential for mouse development [J].

Bernstein, E ;

Kim, SY ;

Carmell, MA ;

Murchison, EP ;

Alcorn, H ;

Li, MZ ;

Mills, AA ;

Elledge, SJ ;

Anderson, KV ;

Hannon, GJ .

NATURE GENETICS, 2003, 35 (03) :215-217

[7] bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila [J].

Brennecke, J ;

Hipfner, DR ;

Stark, A ;

Russell, RB ;

Cohen, SM .

CELL, 2003, 113 (01) :25-36

[8] Gene silencing by double-stranded RNA [J].

Carthew, RW .

CURRENT OPINION IN CELL BIOLOGY, 2001, 13 (02) :244-248

[9] Fragile X-related protein and VIG associate with the RNA interference machinery [J].

Caudy, AA ;

Myers, M ;

Hannon, GJ ;

Hammond, SM .

GENES & DEVELOPMENT, 2002, 16 (19) :2491-2496

[10] MicroRNAs modulate hematopoietic lineage differentiation [J].

Chen, CZ ;

Li, L ;

Lodish, HF ;

Bartel, DP .

SCIENCE, 2004, 303 (5654) :83-86

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