SOCS1 is significantly up-regulated in Nutlin-3-treated p53wild-type B chronic lymphocytic leukemia (B-CLL) samples and shows an inverse correlation with miR-155

被引：14

作者：

di Iasio, Maria Grazia ^{[2
,3
]}

Norcio, Alessia ^{[2
,3
]}

Melloni, Elisabetta ^{[2
,3
]}

Zauli, Giorgio ^{[1
]}

机构：

[1] IRCCS Burlo Garofolo Trieste, Inst Maternal & Child Hlth, I-34100 Trieste, Italy

[2] Univ Ferrara, Dept Morphol & Embryol, I-44100 Ferrara, Italy

[3] Univ Ferrara, LTTA Ctr, I-44100 Ferrara, Italy

来源：

INVESTIGATIONAL NEW DRUGS | 2012年 / 30卷 / 06期

关键词：

Nutlin-3; Primary B-CLL; SOCS1; miRNA-155; ACUTE MYELOID-LEUKEMIA; T-CELLS; EXPRESSION; PATHWAY; METHYLATION; ACTIVATION; MICRORNA; PROTEIN; TRAIL;

D O I：

10.1007/s10637-011-9786-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The basal SOCS1 mRNA levels were significantly lower in p53(mutated) BJAB and MAVER leukemic cell lines with respect to p53(wild-type) SKW6.4 and JVM-2 leukemic cell lines, p53(wild-type) primary B chronic lymphocytic leukemia (B-CLL) cells and primary normal peripheral blood mononuclear cells (PBMC). Moreover, the MDM2 small molecule inhibitor Nutlin-3 significantly increased the levels of SOCS1 mRNA in both primary p53(wild-type) B-CLL cells as well as in p53(wild-type) B leukemic cell lines, but not in p53(mutated) B leukemic cell lines nor in primary PBMC. Of note, a significant inverse correlation was observed between SOCS1 mRNA and miR-155 levels in Nutlin-3-treated primary B-CLL cells and PBMC, suggesting that the miRNA-155/SOCS1 axis represents a potentially important therapeutic target of Nutlin-3 in B-CLL.

引用

收藏

页码：2403 / 2406

页数：4

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