Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array

被引：446

作者：

Eeles, Rosalind A. ^{[1
,2
,3
]}

Al Olama, Ali Amin ^{[4
]}

Benlloch, Sara ^{[4
]}

Saunders, Edward J. ^{[1
]}

Leongamornlert, Daniel A. ^{[1
]}

Tymrakiewicz, Malgorzata ^{[1
]}

Ghoussaini, Maya ^{[4
]}

Luccarini, Craig ^{[4
]}

Dennis, Joe ^{[4
]}

Jugurnauth-Little, Sarah ^{[1
]}

Dadaev, Tokhir ^{[1
]}

Neal, David E. ^{[5
,6
]}

Hamdy, Freddie C. ^{[7
,8
]}

Donovan, Jenny L. ^{[9
]}

Muir, Ken ^{[10
,11
]}

Giles, Graham G. ^{[12
,13
]}

Severi, Gianluca ^{[12
,13
]}

Wiklund, Fredrik ^{[14
]}

Gronberg, Henrik ^{[14
]}

Haiman, Christopher A. ^{[15
]}

Schumacher, Fredrick ^{[15
]}

Henderson, Brian E. ^{[15
]}

Le Marchand, Loic ^{[16
]}

Lindstrom, Sara ^{[17
]}

Kraft, Peter ^{[17
]}

Hunter, David J. ^{[17
]}

Gapstur, Susan ^{[18
]}

Chanock, Stephen J. ^{[19
]}

Berndt, Sonja I. ^{[19
]}

Albanes, Demetrius ^{[20
]}

Andriole, Gerald ^{[21
]}

Schleutker, Johanna ^{[22
,23
,24
]}

Weischer, Maren ^{[25
]}

Canzian, Federico ^{[26
]}

Riboli, Elio ^{[27
]}

Key, Tim J. ^{[28
]}

Travis, Ruth C. ^{[28
]}

Campa, Daniele ^{[26
]}

Ingles, Sue A. ^{[15
]}

John, Esther M. ^{[29
,30
,31
]}

Hayes, Richard B. ^{[32
]}

Pharoah, Paul D. P. ^{[4
]}

Pashayan, Nora ^{[4
]}

Khaw, Kay-Tee ^{[33
]}

Stanford, Janet L. ^{[34
,35
]}

Ostrander, Elaine A. ^{[36
]}

Signorello, Lisa B. ^{[37
,38
]}

Thibodeau, Stephen N. ^{[39
]}

Schaid, Dan ^{[40
]}

Maier, Christiane ^{[41
,42
]}

机构：

[1] Inst Canc Res, Sutton, Surrey, England

[2] Royal Marsden Natl Hlth Serv NHS Fdn, London, England

[3] Royal Marsden Natl Hlth Serv NHS Fdn, Sutton, Surrey, England

[4] Univ Cambridge, Dept Oncol, Ctr Canc Genet Epidemiol, Cambridge, England

[5] Univ Cambridge, Addenbrookes Hosp, Cambridge CB2 2QQ, England

[6] Canc Res UK Cambridge Res Inst, Li Ka Shing Ctr, Cambridge, England

[7] Univ Oxford, Nuffield Dept Surg Sci, Oxford, England

[8] Univ Oxford, John Radcliffe Hosp, Fac Med Sci, Oxford OX3 9DU, England

[9] Univ Bristol, Sch Social & Community Med, Bristol, Avon, England

[10] Univ Warwick, Warwick Med Sch, Coventry CV4 7AL, W Midlands, England

[11] Univ Manchester, Inst Populat Hlth, Manchester, Lancs, England

[12] Canc Council Victoria, Canc Epidemiol Ctr, Carlton, Vic, Australia

[13] Univ Melbourne, Ctr Mol Environm Genet & Analyt Epidemiol, Melbourne, Vic, Australia

[14] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden

[15] Univ So Calif, Kenneth Norris Jr Comprehens Canc Ctr, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA

[16] Univ Hawaii, Ctr Canc, Honolulu, HI 96822 USA

[17] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Program Mol & Genet Epidemiol, Boston, MA 02115 USA

[18] Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30329 USA

[19] NCI, Div Canc Epidemiol & Genet, US Natl Inst Hlth NIH, Bethesda, MD 20892 USA

[20] NCI, Nutr Epidemiol Branch, US NIH, Bethesda, MD 20892 USA

[21] Washington Univ, Sch Med, Div Urol Surg, St Louis, MO 63110 USA

[22] Univ Tampere, Inst Biomed Technol BioMediTech, FIN-33101 Tampere, Finland

[23] FimLab Labs, Tampere, Finland

[24] Univ Turku, Dept Med Biochem & Genet, Turku, Finland

[25] Copenhagen Univ Hosp, Herlev Hosp, Dept Clin Biochem, Herlev, Denmark

[26] German Canc Res Ctr, Genom Epidemiol Grp, Heidelberg, Germany

[27] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England

[28] Univ Oxford, Nuffield Dept Clin Med, Canc Epidemiol Unit, Oxford, England

[29] Canc Prevent Inst Calif, Fremont, CA USA

[30] Stanford Univ, Sch Med, Stanford Canc Inst, Stanford, CA 94305 USA

[31] Stanford Univ, Sch Med, Div Epidemiol, Dept Hlth Res & Policy, Stanford, CA 94305 USA

[32] NYU, Dept Environm Med, Langone Med Ctr, Div Epidemiol, New York, NY 10016 USA

[33] Univ Cambridge, Clin Gerontol Unit, Cambridge, England

[34] Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98104 USA

[35] Univ Washington, Sch Publ Hlth, Dept Epidemiol, Seattle, WA 98195 USA

[36] NHGRI, US NIH, Bethesda, MD 20892 USA

[37] Int Epidemiol Inst, Rockville, MD USA

[38] Vanderbilt Univ, Sch Med, Dept Med,Div Epidemiol, Vanderbilt Epidemiol Ctr,Vanderbilt Ingram Canc C, Nashville, TN 37212 USA

[39] Mayo Clin, Dept Lab Med & Pathol, Rochester, MN USA

[40] Mayo Clin, Dept Hlth Sci Res, Div Biomed Stat & Informat, Rochester, MN USA

[41] Univ Hosp Ulm, Dept Urol, Ulm, Germany

[42] Univ Hosp Ulm, Inst Human Genet, Ulm, Germany

[43] Brigham & Womens Hosp, Div Urol Surg, Dana Farber Canc Inst, Boston, MA 02115 USA

[44] Pomeranian Med Univ, Int Hereditary Canc Ctr, Dept Genet & Pathol, Szczecin, Poland

[45] Univ Utah, Sch Med, Dept Med, Div Genet Epidemiol, Salt Lake City, UT USA

[46] George E Wahlen Dept Vet Affairs Med Ctr, Salt Lake City, UT USA

[47] DKFZ, Div Clin Epidemiol & Aging Res, Heidelberg, Germany

[48] Univ S Florida, H Lee Moffitt Canc Ctr, Div Canc Prevent & Control, Tampa, FL 33682 USA

[49] Med Univ Sofia, Mol Med Ctr, Dept Med Chem & Biochem, Sofia, Bulgaria

[50] Queensland Univ Technol, Australian Prostate Canc Res Ctr, Queensland Inst Hlth & Biomed Innovat, Brisbane, Qld 4001, Australia

来源：

NATURE GENETICS | 2013年 / 45卷 / 04期

基金：

英国医学研究理事会;

关键词：

GENOME-WIDE ASSOCIATION; VARIANTS; HOXB13; PREDISPOSITION; MUTATIONS; MEN;

D O I：

10.1038/ng.2560

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Prostate cancer is the most frequently diagnosed cancer in males in developed countries. To identify common prostate cancer susceptibility alleles, we genotyped 211,155 SNPs on a custom II lumina array (iCOGS) in blood DNA from 25,074 prostate cancer cases and 24,272 controls from the international PRACTICAL Consortium. Twenty-three new prostate cancer susceptibility loci were identified at genomewide significance (P < 5 x 10(-8)). More than 70 prostate cancer susceptibility loci, explaining similar to 30% of the familial risk for this disease, have now been identified. On the basis of combined risks conferred by the new and previously known risk loci, the top 1% of the risk distribution has a 4.7-fold higher risk than the average of the population being profiled. These results will facilitate population risk stratification for clinical studies.

引用

页码：385 / 391

页数：7

共 29 条

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← 1 2 3 →

共 29 条

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Akamatsu, Shusuke ;

Takata, Ryo ;

Haiman, Christopher A. ;

Takahashi, Atsushi ;

Inoue, Takahiro ;

Kubo, Michiaki ;

Furihata, Mutsuo ;

Kamatani, Naoyuki ;

Inazawa, Johji ;

Chen, Gary K. ;

Le Marchand, Loic ;

Kolonel, Laurence N. ;

Katoh, Takahiko ;

Yamano, Yuko ;

Yamakado, Minoru ;

Takahashi, Hiroyuki ;

Yamada, Hiroki ;

Egawa, Shin ;

Fujioka, Tomoaki ;

Henderson, Brian E. ;

Habuchi, Tomonori ;

Ogawa, Osamu ;

Nakamura, Yusuke ;

Nakagawa, Hidewaki .

NATURE GENETICS, 2012, 44 (04) :426-U234

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Al Olama, Ali Amin ;

Kote-Jarai, Zsofia ;

Schumacher, Fredrick R. ;

Wiklund, Fredrik ;

Berndt, Sonja I. ;

Benlloch, Sara ;

Giles, Graham G. ;

Severi, Gianluca ;

Neal, David E. ;

Hamdy, Freddie C. ;

Donovan, Jenny L. ;

Hunter, David J. ;

Henderson, Brian E. ;

Thun, Michael J. ;

Gaziano, Michael ;

Giovannucci, Edward L. ;

Siddiq, Afshan ;

Travis, Ruth C. ;

Cox, David G. ;

Canzian, Federico ;

Riboli, Elio ;

Key, Timothy J. ;

Andriole, Gerald ;

Albanes, Demetrius ;

Hayes, Richard B. ;

Schleutker, Johanna ;

Auvinen, Anssi ;

Tammela, Teuvo L. J. ;

Weischer, Maren ;

Stanford, Janet L. ;

Ostrander, Elaine A. ;

Cybulski, Cezary ;

Lubinski, Jan ;

Thibodeau, Stephen N. ;

Schaid, Daniel J. ;

Sorensen, Karina D. ;

Batra, Jyotsna ;

Clements, Judith A. ;

Chambers, Suzanne ;

Aitken, Joanne ;

Gardiner, Robert A. ;

Maier, Christiane ;

Vogel, Walther ;

Doerk, Thilo ;

Brenner, Hermann ;

Habuchi, Tomonori ;

Ingles, Sue ;

John, Esther M. ;

Dickinson, Joanne L. ;

Cannon-Albright, Lisa .

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Barbieri, Christopher E. ;

Baca, Sylvan C. ;

Lawrence, Michael S. ;

Demichelis, Francesca ;

Blattner, Mirjam ;

Theurillat, Jean-Philippe ;

White, Thomas A. ;

Stojanov, Petar ;

Van Allen, Eliezer ;

Stransky, Nicolas ;

Nickerson, Elizabeth ;

Chae, Sung-Suk ;

Boysen, Gunther ;

Auclair, Daniel ;

Onofrio, Robert C. ;

Park, Kyung ;

Kitabayashi, Naoki ;

MacDonald, Theresa Y. ;

Sheikh, Karen ;

Vuong, Terry ;

Guiducci, Candace ;

Cibulskis, Kristian ;

Sivachenko, Andrey ;

Carter, Scott L. ;

Saksena, Gordon ;

Voet, Douglas ;

Hussain, Wasay M. ;

Ramos, Alex H. ;

Winckler, Wendy ;

Redman, Michelle C. ;

Ardlie, Kristin ;

Tewari, Ashutosh K. ;

Mosquera, Juan Miguel ;

Rupp, Niels ;

Wild, Peter J. ;

Moch, Holger ;

Morrissey, Colm ;

Nelson, Peter S. ;

Kantoff, Philip W. ;

Gabriel, Stacey B. ;

Golub, Todd R. ;

Meyerson, Matthew ;

Lander, Eric S. ;

Getz, Gad ;

Rubin, Mark A. ;

Garraway, Levi A. .

NATURE GENETICS, 2012, 44 (06) :685-U107

[4]

Breast Canc Linkage Consortium, 1999, JNCI-J NATL CANCER I, V91, P1310

[5] Co-expression of the androgen receptor and the transcription factor ZNF652 is related to prostate cancer outcome [J].

Callen, David F. ;

Ricciardelli, Carmela ;

Butler, Miriam ;

Stapleton, Alan ;

Stahl, Jurgen ;

Kench, James G. ;

Horsfall, David J. ;

Tilley, Wayne D. ;

Schulz, Renee ;

Nesland, Jahn M. ;

Neilsen, Paul M. ;

Kumar, Raman ;

Holm, Ruth .

ONCOLOGY REPORTS, 2010, 23 (04) :1045-1052

[6] Genome-Wide Association Study in BRCA1 Mutation Carriers Identifies Novel Loci Associated with Breast and Ovarian Cancer Risk [J].

Couch, Fergus J. ;

Wang, Xianshu ;

McGuffog, Lesley ;

Lee, Andrew ;

Olswold, Curtis ;

Kuchenbaecker, Karoline B. ;

Soucy, Penny ;

Fredericksen, Zachary ;

Barrowdale, Daniel ;

Dennis, Joe ;

Gaudet, Mia M. ;

Dicks, Ed ;

Kosel, Matthew ;

Healey, Sue ;

Sinilnikova, Olga M. ;

Lee, Adam ;

Bacot, Francois ;

Vincent, Daniel ;

Hogervorst, Frans B. L. ;

Peock, Susan ;

Stoppa-Lyonnet, Dominique ;

Jakubowska, Anna ;

Radice, Paolo ;

Schmutzler, Rita Katharina ;

Domchek, Susan M. ;

Piedmonte, Marion ;

Singer, Christian F. ;

Friedman, Eitan ;

Thomassen, Mads ;

Hansen, Thomas V. O. ;

Neuhausen, Susan L. ;

Szabo, Csilla I. ;

Blanco, Ignacio ;

Greene, Mark H. ;

Karlan, Beth Y. ;

Garber, Judy ;

Phelan, Catherine M. ;

Weitzel, Jeffrey N. ;

Montagna, Marco ;

Olah, Edith ;

Andrulis, Irene L. ;

Godwin, Andrew K. ;

Yannoukakos, Drakoulis ;

Goldgar, David E. ;

Caldes, Trinidad ;

Nevanlinna, Heli ;

Osorio, Ana ;

Terry, Mary Beth ;

Daly, Mary B. ;

van Rensburg, Elizabeth J. .

PLOS GENETICS, 2013, 9 (03)

[7] An integrated encyclopedia of DNA elements in the human genome [J].

Dunham, Ian ;

Kundaje, Anshul ;

Aldred, Shelley F. ;

Collins, Patrick J. ;

Davis, CarrieA. ;

Doyle, Francis ;

Epstein, Charles B. ;

Frietze, Seth ;

Harrow, Jennifer ;

Kaul, Rajinder ;

Khatun, Jainab ;

Lajoie, Bryan R. ;

Landt, Stephen G. ;

Lee, Bum-Kyu ;

Pauli, Florencia ;

Rosenbloom, Kate R. ;

Sabo, Peter ;

Safi, Alexias ;

Sanyal, Amartya ;

Shoresh, Noam ;

Simon, Jeremy M. ;

Song, Lingyun ;

Trinklein, Nathan D. ;

Altshuler, Robert C. ;

Birney, Ewan ;

Brown, James B. ;

Cheng, Chao ;

Djebali, Sarah ;

Dong, Xianjun ;

Dunham, Ian ;

Ernst, Jason ;

Furey, Terrence S. ;

Gerstein, Mark ;

Giardine, Belinda ;

Greven, Melissa ;

Hardison, Ross C. ;

Harris, Robert S. ;

Herrero, Javier ;

Hoffman, Michael M. ;

Iyer, Sowmya ;

Kellis, Manolis ;

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