Common variants at 11q12, 10q26 and 3p11.2 are associated with prostate cancer susceptibility in Japanese

被引：100

作者：

Akamatsu, Shusuke ^{[1
,2
]}

Takata, Ryo ^{[1
,3
]}

Haiman, Christopher A. ^{[4
]}

Takahashi, Atsushi ^{[5
]}

Inoue, Takahiro ^{[2
]}

Kubo, Michiaki ^{[6
]}

Furihata, Mutsuo ^{[7
]}

Kamatani, Naoyuki ^{[5
]}

Inazawa, Johji ^{[8
,9
]}

Chen, Gary K. ^{[4
]}

Le Marchand, Loic ^{[10
]}

Kolonel, Laurence N. ^{[10
]}

Katoh, Takahiko ^{[11
]}

Yamano, Yuko ^{[12
]}

Yamakado, Minoru ^{[13
]}

Takahashi, Hiroyuki ^{[14
]}

Yamada, Hiroki ^{[15
]}

Egawa, Shin ^{[15
]}

Fujioka, Tomoaki ^{[3
]}

Henderson, Brian E. ^{[4
]}

Habuchi, Tomonori ^{[16
]}

Ogawa, Osamu ^{[2
]}

Nakamura, Yusuke ^{[17
]}

Nakagawa, Hidewaki ^{[1
]}

机构：

[1] RIKEN, Ctr Genom Med, Lab Biomarker Dev, Tokyo, Japan

[2] Kyoto Univ, Grad Sch Med, Dept Urol, Kyoto, Japan

[3] Iwate Med Univ, Dept Urol, Morioka, Iwate 020, Japan

[4] Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA

[5] RIKEN, Ctr Genom Med, Lab Stat Anal, Yokohama, Kanagawa, Japan

[6] RIKEN, Ctr Genom Med, Lab Genotyping Dev, Tokyo, Japan

[7] Kochi Med Sch, Dept Pathol, Nankoku, Kochi, Japan

[8] Tokyo Med & Dent Univ, Med Res Inst, Dept Mol Cytogenet, Tokyo, Japan

[9] Tokyo Med & Dent Univ, Sch Biomed Sci, Tokyo, Japan

[10] Univ Hawaii, Canc Res Ctr, Program Epidemiol, Honolulu, HI 96813 USA

[11] Kumamoto Univ, Fac Hlth Sci, Dept Publ Hlth, Kumamoto, Japan

[12] Showa Univ, Sch Med, Dept Hyg & Prevent Med, Tokyo 142, Japan

[13] Mitsui Mem Hosp, Ctr Multiphas Hlth Testing & Serv, Tokyo 101, Japan

[14] Jikei Univ, Dept Pathol, Sch Med, Tokyo 105, Japan

[15] Jikei Univ, Sch Med, Dept Urol, Tokyo, Japan

[16] Akita Univ, Sch Med, Dept Urol, Akita 010, Japan

[17] Univ Tokyo, Inst Med Sci, Mol Med Lab, Ctr Human Genome, Tokyo, Japan

来源：

NATURE GENETICS | 2012年 / 44卷 / 04期

基金：

美国国家卫生研究院; 日本学术振兴会;

关键词：

GENOME-WIDE ASSOCIATION; SEQUENCE VARIANTS; ALLELIC LOSS; LOCI; GENE; IDENTIFICATION; REPLICATION; MUTATION; REGION; WDR11;

D O I：

10.1038/ng.1104

中图分类号：

Q3 [遗传学];

学科分类号：

071007 [遗传学];

摘要：

We have previously reported multiple loci associated with prostate cancer susceptibility in a Japanese population using a genome-wide association study (GWAS). To identify additional prostate cancer susceptibility loci, we genotyped nine SNPs that were nominally associated with prostate cancer (P < 1 x 10(-4)) in our previous GWAS in three independent studies of prostate cancer in Japanese men (2,557 individuals with prostate cancer (cases) and 3,003 controls). In a meta-analysis of our previous GWAS and the replication studies, which included a total of 7,141 prostate cancer cases and 11,804 controls from a single ancestry group, three new loci reached genome-wide significance on chromosomes 11q12 (rs1938781; P = 1.10 x 10(-10); FAM111A-FAM111B), 10q26 (rs2252004; P = 1.98 x 10(-8)) and 3p11.2 (rs2055109; P = 3.94 x 10(-8)). We also found suggestive evidence of association at a previously reported prostate cancer susceptibility locus at 2p11 (rs2028898; P = 1.08 x 10(-7)). The identification of three new susceptibility loci should provide additional insight into the pathogenesis of prostate cancer and emphasizes the importance of conducting GWAS in diverse populations.

引用

页码：426 / U234

页数：5

共 28 条

[1]

A functional variant in NKX3.1 associated with prostate cancer susceptibility down-regulates NKX3.1 expression [J].

Akamatsu, Shusuke ;

Takata, Ryo ;

Ashikawa, Kyota ;

Hosono, Naoya ;

Kamatani, Naoyuki ;

Fujioka, Tomoaki ;

Ogawa, Osamu ;

Kubo, Michiaki ;

Nakamura, Yusuke ;

Nakagawa, Hidewaki .

HUMAN MOLECULAR GENETICS, 2010, 19 (21) :4265-4272

[2]

A common variant associated with prostate cancer in European and African populations [J].

Amundadottir, Laufey T. ;

Sulem, Patrick ;

Gudmundsson, Julius ;

Helgason, Agnar ;

Baker, Adam ;

Agnarsson, Bjarni A. ;

Sigurdsson, Asgeir ;

Benediktsdottir, Kristrun R. ;

Cazier, Jean-Baptiste ;

Sainz, Jesus ;

Jakobsdottir, Margret ;

Kostic, Jelena ;

Magnusdottir, Droplaug N. ;

Ghosh, Shyamali ;

Agnarsson, Kari ;

Birgisdottir, Birgitta ;

Le Roux, Louise ;

Olafsdottir, Adalheidur ;

Blondal, Thorarinn ;

Andresdottir, Margret ;

Gretarsdottir, Olafia Svandis ;

Bergthorsson, Jon T. ;

Gudbjartsson, Daniel ;

Gylfason, Arnaldur ;

Thorleifsson, Gudmar ;

Manolescu, Andrei ;

Kristjansson, Kristleifur ;

Geirsson, Gudmundur ;

Isaksson, Helgi ;

Douglas, Julie ;

Johansson, Jan-Erik ;

Balter, Katarina ;

Wiklund, Fredrik ;

Montie, James E. ;

Yu, Xiaoying ;

Suarez, Brian K. ;

Ober, Carole ;

Cooney, Kathleen A. ;

Gronberg, Henrik ;

Catalona, William J. ;

Einarsson, Gudmundur V. ;

Barkardottir, Rosa B. ;

Gulcher, Jeffrey R. ;

Kong, Augustine ;

Thorsteinsdottir, Unnur ;

Stefansson, Kari .

NATURE GENETICS, 2006, 38 (06) :652-658

[3]

Deregulation of the Pit-1 transcription factor in human breast cancer cells promotes tumor growth and metastasis [J].

Ben-Batalla, Isabel ;

Seoane, Samuel ;

Garcia-Caballero, Tomas ;

Gallego, Rosalia ;

Macia, Manuel ;

Gonzalez, Luis O. ;

Vizoso, Francisco ;

Perez-Fernandez, Roman .

JOURNAL OF CLINICAL INVESTIGATION, 2010, 120 (12) :4289-4302

[4]

The vitamin K-dependent carboxylase [J].

Berkner, KL .

ANNUAL REVIEW OF NUTRITION, 2005, 25 :127-149

[5]

A missense mutation in γ-glutamyl carboxylase gene causes combined deficiency of all vitamin K-dependent blood coagulation factors [J].

Brenner, B ;

Sánchez-Vega, B ;

Wu, SM ;

Lanir, N ;

Stafford, DV ;

Solera, J .

BLOOD, 1998, 92 (12) :4554-4559

[6]

A novel member of the WD-repeat gene family, WDR11, maps to the 10q26 region and is disrupted by a chromosome translocation in human glioblastoma cells [J].

Chernova, OB ;

Hunyadi, A ;

Malaj, E ;

Pan, HQ ;

Crooks, C ;

Roe, B ;

Cowell, JK .

ONCOGENE, 2001, 20 (38) :5378-5392

[7]

Tumour suppressor genes in the pathogenesis of human pituitary tumours [J].

Clayton, RN ;

Boggild, M ;

Bates, AS ;

Bicknell, J ;

Simpson, D ;

Farrell, W .

HORMONE RESEARCH, 1997, 47 (4-6) :185-193

[8]

Rare Variants Create Synthetic Genome-Wide Associations [J].

Dickson, Samuel P. ;

Wang, Kai ;

Krantz, Ian ;

Hakonarson, Hakon ;

Goldstein, David B. .

PLOS BIOLOGY, 2010, 8 (01)

[9]

Multiple newly identified loci associated with prostate cancer susceptibility [J].

Eeles, Rosalind A. ;

Kote-Jarai, Zsofia ;

Giles, Graham G. ;

Al Olama, Ali Amin ;

Guy, Michelle ;

Jugurnauth, Sarah K. ;

Mulholland, Shani ;

Leongamornlert, Daniel A. ;

Edwards, Stephen M. ;

Morrison, Jonathan ;

Field, Helen I. ;

Southey, Melissa C. ;

Severi, Gianluca ;

Donovan, Jenny L. ;

Hamdy, Freddie C. ;

Dearnaley, David P. ;

Muir, Kenneth R. ;

Smith, Charmaine ;

Bagnato, Melisa ;

Ardern-Jones, Audrey T. ;

Hall, Amanda L. ;

O'Brien, Lynne T. ;

Gehr-Swain, Beatrice N. ;

Wilkinson, Rosemary A. ;

Cox, Angie ;

Lewis, Sarah ;

Brown, Paul M. ;

Jhavar, Sameer G. ;

Tymrakiewicz, Malgorzata ;

Lophatananon, Artitaya ;

Bryant, Sarah L. ;

Horwich, Alan ;

Huddart, Robert A. ;

Khoo, Vincent S. ;

Parker, Christopher C. ;

Woodhouse, Christopher J. ;

Thompson, Alan ;

Christmas, Tim ;

Ogden, Chris ;

Fisher, Cyril ;

Jamieson, Charles ;

Cooper, Colin S. ;

English, Dallas R. ;

Hopper, John L. ;

Neal, David E. ;

Easton, Douglas F. .

NATURE GENETICS, 2008, 40 (03) :316-321

[10]

Identification of seven new prostate cancer susceptibility loci through a genome-wide association study [J].

Eeles, Rosalind A. ;

Kote-Jarai, Zsofia ;

Al Olama, Ali Amin ;

Giles, Graham G. ;

Guy, Michelle ;

Severi, Gianluca ;

Muir, Kenneth ;

Hopper, John L. ;

Henderson, Brian E. ;

Haiman, Christopher A. ;

Schleutker, Johanna ;

Hamdy, Freddie C. ;

Neal, David E. ;

Donovan, Jenny L. ;

Stanford, Janet L. ;

Ostrander, Elaine A. ;

Ingles, Sue A. ;

John, Esther M. ;

Thibodeau, Stephen N. ;

Schaid, Daniel ;

Park, Jong Y. ;

Spurdle, Amanda ;

Clements, Judith ;

Dickinson, Joanne L. ;

Maier, Christiane ;

Vogel, Walther ;

Doerk, Thilo ;

Rebbeck, Timothy R. ;

Cooney, Kathleen A. ;

Cannon-Albright, Lisa ;

Chappuis, Pierre O. ;

Hutter, Pierre ;

Zeegers, Maurice ;

Kaneva, Radka ;

Zhang, Hong-Wei ;

Lu, Yong-Jie ;

Foulkes, William D. ;

English, Dallas R. ;

Leongamornlert, Daniel A. ;

Tymrakiewicz, Malgorzata ;

Morrison, Jonathan ;

Ardern-Jones, Audrey T. ;

Hall, Amanda L. ;

O'Brien, Lynne T. ;

Wilkinson, Rosemary A. ;

Saunders, Edward J. ;

Page, Elizabeth C. ;

Sawyer, Emma J. ;

Edwards, Stephen M. ;

Dearnaley, David P. .

NATURE GENETICS, 2009, 41 (10) :1116-U97

← 1 2 3 →