Identification of seven new prostate cancer susceptibility loci through a genome-wide association study

被引:332
作者
Eeles, Rosalind A. [1 ,2 ,3 ]
Kote-Jarai, Zsofia [1 ]
Al Olama, Ali Amin [4 ]
Giles, Graham G. [5 ,6 ]
Guy, Michelle [1 ]
Severi, Gianluca [5 ,6 ]
Muir, Kenneth [7 ]
Hopper, John L. [6 ]
Henderson, Brian E. [8 ]
Haiman, Christopher A. [8 ]
Schleutker, Johanna [9 ]
Hamdy, Freddie C. [10 ]
Neal, David E. [11 ]
Donovan, Jenny L. [12 ]
Stanford, Janet L. [13 ,14 ]
Ostrander, Elaine A. [15 ]
Ingles, Sue A.
John, Esther M. [16 ,17 ]
Thibodeau, Stephen N. [18 ]
Schaid, Daniel [18 ]
Park, Jong Y. [19 ]
Spurdle, Amanda [20 ]
Clements, Judith [21 ,22 ,23 ]
Dickinson, Joanne L. [24 ]
Maier, Christiane [25 ]
Vogel, Walther [25 ]
Doerk, Thilo [26 ,27 ]
Rebbeck, Timothy R. [28 ,29 ]
Cooney, Kathleen A. [30 ,31 ]
Cannon-Albright, Lisa [32 ]
Chappuis, Pierre O. [33 ,34 ]
Hutter, Pierre [35 ]
Zeegers, Maurice [36 ,37 ]
Kaneva, Radka [38 ,39 ]
Zhang, Hong-Wei [40 ]
Lu, Yong-Jie [41 ]
Foulkes, William D. [42 ]
English, Dallas R. [6 ]
Leongamornlert, Daniel A. [1 ]
Tymrakiewicz, Malgorzata [1 ]
Morrison, Jonathan [4 ]
Ardern-Jones, Audrey T. [2 ,3 ]
Hall, Amanda L. [1 ,2 ,3 ]
O'Brien, Lynne T. [1 ]
Wilkinson, Rosemary A. [1 ]
Saunders, Edward J. [1 ]
Page, Elizabeth C. [1 ,2 ,3 ]
Sawyer, Emma J. [1 ]
Edwards, Stephen M. [1 ]
Dearnaley, David P. [1 ,2 ,3 ]
机构
[1] Inst Canc Res, Surrey, England
[2] Royal Marsden Natl Hlth Serv Fdn Trust, Surrey, England
[3] Royal Marsden Natl Hlth Serv Fdn Trust, London, England
[4] Univ Cambridge, Canc Res UK Genet Epidemiol Unit, Dept Publ Hlth & Primary Care, Strangeways Lab, Cambridge, England
[5] Canc Council Victoria, Canc Epidemiol Ctr, Carlton, Vic, Australia
[6] Univ Melbourne, Ctr Mol Environm Genet & Analyt Epidemiol, Carlton, Vic 3053, Australia
[7] Univ Nottingham, Sch Med, Queens Med Ctr, Nottingham, England
[8] Univ So Calif, Keck Sch Med, Dept Prevent Med, Kenneth Norris Jr Comprehens Canc Ctr, Los Angeles, CA 90033 USA
[9] Univ Tampere, Inst Med Technol, FIN-33101 Tampere, Finland
[10] Univ Oxford, Nuffield Dept Surg, Oxford, England
[11] Li Ka Shing Ctr, Canc Res UK Cambridge Res Inst, Cambridge, England
[12] Univ Bristol, Dept Social Med, Bristol, Avon, England
[13] Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98104 USA
[14] Univ Washington, Sch Publ Hlth & Community Med, Dept Epidemiol, Seattle, WA 98195 USA
[15] NHGRI, NIH, Bethesda, MD 20892 USA
[16] No Calif Canc Ctr, Fremont, CA USA
[17] Stanford Univ, Sch Med, Stanford, CA 94305 USA
[18] Mayo Clin, Rochester, MN USA
[19] Univ S Florida, H Lee Moffitt Canc Ctr, Div Canc Prevent & Control, Tampa, FL 33682 USA
[20] Queensland Inst Med Res, Mol Canc Epidemiol Lab, Brisbane, Qld 4006, Australia
[21] Queensland Univ Technol, Australian Prostate Canc Res Ctr Queensland, Inst Hlth & Biomed Innovat, Brisbane, Qld 4001, Australia
[22] Queensland Univ Technol, Sch Life Sci, Brisbane, Qld 4001, Australia
[23] Queensland Univ Technol, Sch Publ Hlth, Brisbane, Qld 4001, Australia
[24] Univ Tasmania, Menzies Res Inst, Hobart, Tas, Australia
[25] Inst Human Genet & Anthropol, Ulm, Germany
[26] Hannover Med Sch, Clin Obstet, D-3000 Hannover, Germany
[27] Hannover Med Sch, Clin Gynaecol, D-3000 Hannover, Germany
[28] Univ Penn, Ctr Clin Epidemiol & Biostat, Philadelphia, PA 19104 USA
[29] Univ Penn, Abramson Canc Ctr, Philadelphia, PA 19104 USA
[30] Univ Michigan, Sch Med, Dept Internal Med, Ann Arbor, MI USA
[31] Univ Michigan, Sch Med, Dept Urol, Ann Arbor, MI USA
[32] Univ Utah, Sch Med, Dept Biomed Informat, Salt Lake City, UT USA
[33] Univ Hosp Geneva, Div Med Genet, Geneva, Switzerland
[34] Univ Hosp Geneva, Div Oncol, Geneva, Switzerland
[35] Inst Cent Hop Valaisans, Div Med Genet, Sion, Switzerland
[36] Univ Birmingham, Unit Genet Epidemiol, Dept Publ Hlth Epidemiol & Biostat, Sch Med, Birmingham B15 2TT, W Midlands, England
[37] Maastricht Univ, Dept Complex Genet, Cluster Genet & Cell Biol, Nutr & Toxicol Res Inst,Med Ctr, Maastricht, Netherlands
[38] Med Univ Sofia, Mol Med Ctr, Sofia, Bulgaria
[39] Med Univ Sofia, Dept Chem & Biochem, Sofia, Bulgaria
[40] Second Mil Med Univ, Dept Epidemiol, Shanghai, Peoples R China
[41] Univ London, Inst Canc, Barts & London Sch Med & Dent, London, England
[42] McGill Univ, Program Canc Genet, Montreal, PQ, Canada
[43] Univ Melbourne, Dept Pathol, Genet Epidemiol Lab, Parkville, Vic 3052, Australia
[44] Chulabhorn Canc Res Ctr, Bangkok, Thailand
[45] Univ Hawaii, Canc Res Ctr, Program Epidemiol, Honolulu, HI 96813 USA
[46] Univ Tampere, Sch Med, FIN-33101 Tampere, Finland
[47] Tampere Univ Hosp, Dept Urol, Tampere, Finland
[48] Univ Tampere, Tampere Sch Publ Hlth, FIN-33101 Tampere, Finland
[49] Univ Sheffield, Inst Canc Studies, Sheffield, S Yorkshire, England
[50] Univ Washington, Sch Publ Hlth & Community Med, Dept Biostat, Seattle, WA 98195 USA
基金
英国医学研究理事会;
关键词
AUSTRALIAN CASE-CONTROL; MULTIPLE; RISK; VARIANTS; ANTIGEN;
D O I
10.1038/ng.450
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Prostate cancer (PrCa) is the most frequently diagnosed cancer in males in developed countries. To identify common PrCa susceptibility alleles, we previously conducted a genome-wide association study in which 541,129 SNPs were genotyped in 1,854 PrCa cases with clinically detected disease and in 1,894 controls. We have now extended the study to evaluate promising associations in a second stage in which we genotyped 43,671 SNPs in 3,650 PrCa cases and 3,940 controls and in a third stage involving an additional 16,229 cases and 14,821 controls from 21 studies. In addition to replicating previous associations, we identified seven new prostate cancer susceptibility loci on chromosomes 2, 4, 8, 11 and 22 (with P = 1.6 x 10(-8) to P = 2.7 x 10(-33)).
引用
收藏
页码:1116 / U97
页数:8
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