Preparation and evaluation of unimolecular pentavalent and hexavalent antigenic constructs targeting prostate and breast cancer: A synthetic route to anticancer vaccine candidates

被引：125

作者：

Ragupathi, G

Koide, F

Livingston, PO

Cho, YS

Endo, A

Wan, Q

Spassova, MK

Keding, SJ

Allen, J

Ouerfelli, O

Wilson, RM

Danishefsky, SJ

机构：

[1] Sloan Kettering Inst Canc Res, Bioorgan Chem Lab, New York, NY 10021 USA

[2] Sloan Kettering Inst Canc Res, Lab Tumor Vaccinol, Clin Immunol Serv, Dept Med, New York, NY 10021 USA

[3] Sloan Kettering Inst Canc Res, Organ Synth Core Lab, New York, NY 10021 USA

[4] Columbia Univ, Dept Chem, New York, NY 10027 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2006年 / 128卷 / 08期

关键词：

D O I：

10.1021/ja057244+

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Several novel, fully synthetic, carbohydrate-based antitumor vaccines have been assembled. Each construct consists of multiple cancer-related antigens displayed on a single polypeptide backbone. Recent advances in synthetic methodology have allowed for the incorporation of a complex oligosaccharide terminating in a sialic acid residue (i.e., GM2) as one of the carbohydrate antigens. Details of the vaccine synthesis as well as the results of preliminary immunological investigations are described herein.

引用

页码：2715 / 2725

页数：11

共 30 条

[1] Pursuit of optimal carbohydrate-based anticancer vaccines:: Preparation of a multiantigenic unimolecular glycopeptide containing the Tn, MBr1, and Lewisy antigens [J].