Regulation of human skeletal stem cells differentiation by Dlk1/Pref-1

被引：196

作者：

Abdallah, BM

Jensen, CH

Gutierrez, G

Leslie, RGQ

Jensen, TG

Kassem, M

机构：

[1] Odense Univ Hosp, Dept Endocrinol, DK-5000 Odense, Denmark

[2] Univ So Denmark, Dept Microbiol & Immunol, Med Biol Inst, Odense, Denmark

[3] OsteoScreen Ltd, San Antonio, TX USA

[4] Univ Aarhus, Dept Human Genet, Aarhus, Denmark

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2004年 / 19卷 / 05期

关键词：

stem cells; osteoblasts; adipocytes; differentiation; preadipocyte factor-1; fetal antigen 1;

D O I：

10.1359/JBMR.040118

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Dlk-1/Pref-1 was identified as a novel regulator of human skeletal stem cell differentiation. Dlk1/Pref-1 is expressed in bone and cultured osteoblasts, and its constitutive overexpression led to inhibition of osteoblast and adipocyte differentiation of human marrow stromal cells.

引用

页码：841 / 852

页数：12

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