An alternative synthesis of [11C]raclopride for routine use

被引：19

作者：

Ishiwata, K ^{[1
]}

Ishii, S ^{[1
]}

Senda, M ^{[1
]}

机构：

[1] Tokyo Metropolitan Inst Gerontol, Positron Med Ctr, Itabashi Ku, Tokyo 1730022, Japan

来源：

ANNALS OF NUCLEAR MEDICINE | 1999年 / 13卷 / 03期

关键词：

C-11]raclopride; dopamine D-2 receptor; PET;

D O I：

10.1007/BF03164862

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The standard method of [C-11]raclopride synthesis requires a large amount of its desmethyl precursor. We prepared [C-11]raclopride by methylation of a small amount of desmethyl derivative (0.3-0.5 mg) with [C-11]methyl iodide in a DMF solution containing NaH, with a decay-corrected radiochemical yield of 11-14% based on [C-11]methyl iodide and with a specific activity of 48 TBq/mmol for 25 min from EOB. The reaction was reproducible and reliable.

引用

页码：195 / 197

页数：3

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