Sphingosine-1-phosphate and sphingosylphosphorylcholine: two of a kind?

被引:7
作者
Alewijnse, AE [1 ]
Michel, MC [1 ]
机构
[1] Univ Amsterdam, Acad Med Ctr, Dept Pharmacol & Pharmacotherapy, NL-1105 AZ Amsterdam, Netherlands
关键词
proton-sensing receptor; S1P receptor; sphingosine-1-phosphate; sphingosylphosphorylcholine;
D O I
10.1038/sj.bjp.0706602
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Sphingosine-1-phosphate and sphingosylphosphorylcholine are structurally related signalling molecules. Although they share some biological effects, it is debated whether this involves the same receptors. In this issue, Mathieson and Nixon report that these two lipids activate the same transcription factor but do so via distinct signalling pathways. Against this background, we discuss some of the potential pitfalls in studies comparing the effects of the two sphingolipids.
引用
收藏
页码:347 / 348
页数:2
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