An automated radiosynthesis of 2-[11C]thymidine using anhydrous [11C]urea derived from[11C]phosgene

被引：35

作者：

Steel, CJ ^{[1
]}

Brady, F ^{[1
]}

Luthra, SK ^{[1
]}

Brown, G ^{[1
]}

Khan, I ^{[1
]}

Poole, KG ^{[1
]}

Sergis, A ^{[1
]}

Jones, T ^{[1
]}

Price, PM ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, MRC, Cyclotron Unit, London W12 0HS, England

来源：

APPLIED RADIATION AND ISOTOPES | 1999年 / 51卷 / 04期

关键词：

D O I：

10.1016/S0969-8043(99)00051-2

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

2-[C-11]Thymidine has been produced from [C-11]methane via [C-11]phosgene and [C-11]urea. Anhydrous [C-11]urea was prepared from [C-11]phosgene by reaction with liquid ammonia. This novel approach avoids the problems associated with the synthesis of anhydrous [C-11]urea from [C-11]cyanide. A fully automated system based on a modular approach and under PLC control has been developed. The system provides 2-[C-11]thymidine reliably and reproducibly for clinical PET studies. The radiosynthesis takes 45-50 min from [C-11]methane and the average yield was 1.5-3.3 GBq (40-90 mCi). The specific radioactivity was typically in the range 29.6-51.8 GBq mu mol(-1) (0.8-1.4 Ci mu mol(-1)) at EOS corresponding to 6-12 mu g of stable thymidine. The radiochemical yield of 2-[C-11]thymidine was ca. 14% from [C-11]methane. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：377 / 388

页数：12

共 38 条

[1] SELECTIVE ALKYLATION OF PYRIMIDYL DIANIONS .3. NO-CARRIER-ADDED SYNTHESIS OF [C-11-METHYL]-THYMIDINE [J].