Polydnaviruses of Braconid Wasps Derive from an Ancestral Nudivirus

被引：220

作者：

Bezier, Annie ^{[1
]}

Annaheim, Marc ^{[2
]}

Herbiniere, Juline ^{[1
]}

Wetterwald, Christoph ^{[2
]}

Gyapay, Gabor ^{[4
]}

Bernard-Samain, Sylvie ^{[4
]}

Wincker, Patrick ^{[4
]}

Roditi, Isabel ^{[2
]}

Heller, Manfred ^{[3
]}

Belghazi, Maya ^{[5
]}

Pfister-Wilhem, Rita ^{[2
]}

Periquet, Georges ^{[1
]}

Dupuy, Catherine ^{[1
]}

Huguet, Elisabeth ^{[1
]}

Volkoff, Anne-Nathalie ^{[6
]}

Lanzrein, Beatrice ^{[2
]}

Drezen, Jean-Michel ^{[1
]}

机构：

[1] Univ Tours, Inst Rech Biol Insecte, CNRS, UMR 6035, F-37200 Tours, France

[2] Univ Bern, Inst Cell Biol, CH-3012 Bern, Switzerland

[3] Univ Bern, Dept Clin Res, CH-3010 Bern, Switzerland

[4] Genoscope Ctr Natl Sequencage, CEA, F-91057 Evry, France

[5] Ctr Anal Proteom Marseille, Inst Federatif Rech J Roche IFR11, INSERM, Fac Med, F-13916 Marseille 20, France

[6] Univ Montpellier 2, INRA, UMR 1231, F-34095 Montpellier 5, France

来源：

SCIENCE | 2009年 / 323卷 / 5916期

基金：

瑞士国家科学基金会;

关键词：

GENOME SEQUENCE; CHELONUS-INANITUS; VIRUS; DNA; EVOLUTION; REPLICATION; GENES; SYMBIOSIS; INSIGHTS; REVEALS;

D O I：

10.1126/science.1166788

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Many species of parasitoid wasps inject polydnavirus particles in order to manipulate host defenses and development. Because the DNA packaged in these particles encodes almost no viral structural proteins, their relation to viruses has been debated. Characterization of complementary DNAs derived from braconid wasp ovaries identified genes encoding subunits of a viral RNA polymerase and structural components of polydnavirus particles related most closely to those of nudiviruses- a sister group of baculoviruses. The conservation of this viral machinery in different braconid wasp lineages sharing polydnaviruses suggests that parasitoid wasps incorporated a nudivirus- related genome into their own genetic material. We found that the nudiviral genes themselves are no longer packaged but are actively transcribed and produce particles used to deliver genes essential for successful parasitism in lepidopteran hosts.

引用

页码：926 / 930

页数：5

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