Perchloric acid impregnated on silica gel (HClO4/SiO2):: A versatile catalyst for Michael addition of thiols to the electron-deficient alkenes

被引：72

作者：

Khan, Abu T. ^{[1
]}

Ghosh, Subrata ^{[1
]}

Choudhury, Lokman H. ^{[1
]}

机构：

[1] Indian Inst Technol, Dept Chem, Gauhati 781039, India

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2006年 / 2006卷 / 09期

关键词：

Thiols; electron-deficient alkenes; Michael addition; silica-supported perchloric acid;

D O I：

10.1002/ejoc.200600006

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Perchloric acid adsorbed on silica gel (HClO4/SiO2) has been found to be a highly efficient and versatile catalyst for the Michael addition of thiols to a wide variety of conjugated alkenes such as alpha,beta-unsaturated ketones, carboxylic esters, nitriles, amides and chalcones in dichloromethane or methanol at room temperature. The reactions are completed within 2-20 min in high yields. Some of the additional advantages are: no aqueous work-up is necessary, and the catalyst is also reusable. Moreover, the solid product can be obtained without chromatographic separation.

引用

页码：2226 / 2231

页数：6

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