Hepatitis C virus (HCV) employs multiple strategies to subvert the host innate antiviral response

被引：33

作者：

Bode, Johannes G. ^{[1
]}

Brenndoerfer, Erwin D. ^{[1
]}

Haeussinger, Dieter ^{[1
]}

机构：

[1] Univ Dusseldorf, Univ Hosp, Dept Gastroenterol Hepatol & Infectiol, D-40225 Dusseldorf, Germany

来源：

BIOLOGICAL CHEMISTRY | 2008年 / 389卷 / 10期

关键词：

hepatitis C; innate immunity; interferon signaling; pathogen-associated molecular pattern; pathogen recognition receptors; retinoic acid-inducible gene I;

D O I：

10.1515/BC.2008.147

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hepatitis C virus (HCV) is a serious global health problem which accounts for approximately 40% of chronic liver diseases worldwide. HCV frequently establishes a persistent infection, although it is recognized and targeted by innate immunity as well as cellular and humoral immune mechanisms. This suggests that HCV has developed powerful strategies to escape elimination by innate and adaptive immunity. HCV-induced liver injury is thought to be mainly immune-mediated rather than due to direct cytopathic effects of the virus. Hence, therapeutic strategies should target those mechanisms favoring viral persistence since unspecific enhancement of host antiviral immunity may theoretically also promote liver injury. The present review summarizes our current understanding of how the hepatitis C virus interferes with the innate antiviral host-response to establish persistent infection.

引用

页码：1283 / 1298

页数：16

共 179 条

[1] Hepatitis C Lipo-Viro-Particle from Chronically Infected Patients Interferes with TLR4 Signaling in Dendritic Cell [J].