Telomeres, aging and cancer: In search of a happy ending

被引：155

作者：

Kim, S ^{[1
]}

Kaminker, P ^{[1
]}

Campisi, J ^{[1
]}

机构：

[1] Univ Calif Berkeley, Lawrence Berkeley Lab, Div Life Sci, Berkeley, CA 94720 USA

来源：

ONCOGENE | 2002年 / 21卷 / 04期

关键词：

antagonistic pleiotropy; cellular senescence; genomic instability; immortalization; telomerase; tumor suppression;

D O I：

10.1038/sj.onc.1205077

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Telomeres are distinctive structures, composed of a repetitive DNA sequence and associated proteins, that cap the ends of linear chromosomes. Telomeres are essential for maintaining the integrity and stability of eukaryotic genomes. In addition, under some circumstances, telomeres can influence cellular gene expression. In mammals, the length, structure, and function of telomeres have been proposed to contribute to cellular and organismal phenotypes associated with cancer and aging. Here, we discuss what is known about the basis for the links between telomeres, aging and cancer, and some of the known and proposed consequences of telomere dysfunction and maintenance for mammalian cells and organisms.

引用

页码：503 / 511

页数：9

共 108 条

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