Acetyl and butyrylcholinesterase-inhibiting triterpenoid alkaloids from Buxus papillosa

被引：64

作者：

Atta-Ur-Rahman ^{[1
]}

Parveen, S ^{[1
]}

Khalid, A ^{[1
]}

Farooq, A ^{[1
]}

Choudhary, MI ^{[1
]}

机构：

[1] Univ Karachi, Int Ctr Chem Sci, HEJ Res Inst Chem, Karachi 75270, Pakistan

来源：

PHYTOCHEMISTRY | 2001年 / 58卷 / 06期

关键词：

Buxus papillosa; Buxaceae; triterpenoid alkaloids; buxakashmiramine; buxakarachiamine; buxahejramine; anticholinesterase activity;

D O I：

10.1016/S0031-9422(01)00332-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Three triterpenoid alkaloids. buxakashiniramine [(20S)-20-dimethylamino-4,6'-dimethoxy-5'-hydroxybenzoylamino-3 beta -methylbuxan-31-ol] (1), buxakarachiamine [(20S)-20-dimetliylamino-2'-hydroxy-3 beta -methyl-3'-methyl-butanoylamino-9,10-seco-buxa-9(11), 10(19)-dien-31-ol] (2) and buxaehjramme [(20S)-20-dimethylamino-2'-hydroxy-3 beta -methyl-3'-methyl-pentanoylamino-9,10-seco-buxa-9(11), 10(19)-dien-31-ol] (3) were isolated from the leaves of Buxus papillosa. Four known bases, cycloprotobuxine-C (4), cyclovirobuxeine-A (5), cyclomicrophylline-A (6) and semperviraminol (7) were isolated for the first time from this species. Their structures were established through extensive spectroscopic studies. Most of these compounds exhibited anticholinesterase activity. (C) 2001 Published by Elsevier Science Ltd.

引用

页码：963 / 968

页数：6

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