A Supramolecular Antibiotic Switch for Antibacterial Regulation

被引：345

作者：

Bai, Haotian ^{[1
]}

Yuan, Huanxiang ^{[1
]}

Nie, Chenyao ^{[1
]}

Wang, Bing ^{[1
]}

Lv, Fengting ^{[1
]}

Liu, Libing ^{[1
]}

Wang, Shu ^{[1
]}

机构：

[1] Chinese Acad Sci, Beijing Natl Lab Mol Sci, Inst Chem, Key Lab Organ Solids, Beijing 100190, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2015年 / 54卷 / 45期

基金：

中国国家自然科学基金;

关键词：

antibacterial regulation; antibiotics; bacterial resistance; supramolecular assembly; molecular switches; SOLUBLE CONJUGATED POLYMERS; ENERGY-TRANSFER; RESISTANCE GENES; DISCOVERY; POLYELECTROLYTES; RECOGNITION; BACTERIAL; SYSTEMS; DRUGS; DNA;

D O I：

10.1002/anie.201504566

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

A supramolecular antibiotic switch is described that can reversibly turn-on and turn-off its antibacterial activity on demand, providing a proof-of-concept for a way to regulate antibacterial activity of biotics. The switch relies on supramolecular assembly and disassembly of cationic poly(phenylene vinylene) derivative (PPV) with cucurbit[7]uril (CB[7]) to regulate their different interactions with bacteria. This simple but efficient strategy does not require any chemical modification on the active sites of the antibacterial agent, and could also regulate the antibacterial activity of classical antibiotics or photosensitizers in photodynamic therapy. This supramolecular antibiotic switch may be a successful strategy to fight bacterial infections and decrease the emergence of bacterial resistance to antibiotics from a long-term point of view.

引用

页码：13208 / 13213

页数：6

共 30 条

[1]

[Anonymous], 2013, ANGEW CHEM, V125, P8443

[2]

Indirect detection of photosensitizer ex vivo [J].