A new [4+2] cycloaddition strategy for the synthesis of N-acyl-7-azabicyclo[2.2.1]heptan-2-ones: A formal synthesis of (+/-)-epibatidine

被引：35

作者：

Pavri, NP ^{[1
]}

Trudell, ML ^{[1
]}

机构：

[1] UNIV NEW ORLEANS,DEPT CHEM,NEW ORLEANS,LA 70148

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 46期

关键词：

D O I：

10.1016/S0040-4039(97)10179-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

N-Acyl-7-azabicyclo[2.2.1]heptan-2-one derivatives were prepared from N-acyl pyrroles via a [4 + 2] cycloaddition reaction with allenes. This represents a new synthetic approach for the synthesis of epibatidine and related analogs. (C) 1997 Elsevier Science Ltd.

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页码：7993 / 7996

页数：4

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