THE SYNTHESIS OF (+)-EPIBATIDINE AND (-)-EPIBATIDINE

被引：71

作者：

FLETCHER, SR ^{[1
]}

BAKER, R ^{[1
]}

CHAMBERS, MS ^{[1
]}

HOBBS, SC ^{[1
]}

MITCHELL, PJ ^{[1
]}

机构：

[1] MERCK SHARP & DOHME LTD,NEUROSCI RES CTR,TERLINGS PK,EASTWICK RD,HARLOW CM20 2QR,ESSEX,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1993年 / 15期

关键词：

D O I：

10.1039/c39930001216

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The synthesis of the alkaloid epibatidine {exo-2-(2-chloro-5-pyridyl)-7-azabicyclo[2.2,1]heptane} in enantiomeric form involving, as the critical step, reaction or 5-lithio-2-chloropyridine with N-tert-butoxycarbonyl-7-azabicyclo[2.2.1]heptan-2-one is described.

引用

页码：1216 / 1218

页数：3

共 7 条

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