Human memory T cells: generation, compartmentalization and homeostasis

被引：703

作者：

Farber, Donna L. ^{[1
,2
,3
]}

Yudanin, Naomi A. ^{[1
,2
]}

Restifo, Nicholas P. ^{[4
]}

机构：

[1] Columbia Univ, Med Ctr, Columbia Ctr Translat Immunol, New York, NY 10032 USA

[2] Columbia Univ, Med Ctr, Dept Microbiol & Immunol, New York, NY 10032 USA

[3] Columbia Univ, Med Ctr, Dept Surg, New York, NY 10032 USA

[4] NCI, NIH, Bethesda, MD 20892 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2014年 / 14卷 / 01期

基金：

美国国家卫生研究院;

关键词：

RESPIRATORY SYNCYTIAL VIRUS; EPSTEIN-BARR-VIRUS; HIGHLY PATHOGENIC SIV; HUMAN BONE-MARROW; EFFECTOR-MEMORY; RESIDENT MEMORY; CUTTING EDGE; IMMUNOLOGICAL MEMORY; CROSS-REACTIVITY; INFLUENZA-VIRUS;

D O I：

10.1038/nri3567

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Memory T cells constitute the most abundant lymphocyte population in the body for the majority of a person's lifetime; however, our understanding of memory T cell generation, function and maintenance mainly derives from mouse studies, which cannot recapitulate the exposure to multiple pathogens that occurs over many decades in humans. In this Review, we discuss studies focused on human memory T cells that reveal key properties of these cells, including subset heterogeneity and diverse tissue residence in multiple mucosal and lymphoid tissue sites. We also review how the function and the adaptability of human memory T cells depend on spatial and temporal compartmentalization.

引用

页码：24 / 35

页数：12

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