Karyomegaly of tubular cells as early stage marker of the nephrotoxicity induced by ochratoxin A in rats

被引:41
作者
Maaroufi, K
Zakhama, A
Baudrimont, I
Achour, A
Abid, S
Ellouz, F
Dhouib, S
Creppy, EE
Bacha, H
机构
[1] Univ Bordeaux 2, Lab Toxicol & Hyg Appl, F-33076 Bordeaux, France
[2] Fac Med Dent, Lab Biochim & Toxicol Mol, Monastir 5019, Tunisia
[3] Fac Med, Anat Pathol Lab, Monastir 5019, Tunisia
[4] CHU, Serv Nephrol, Monastir 5019, Tunisia
关键词
ochratoxin A; karyomegaly; megacytosis; renal tubular cells; abnormal mitosis; apoptotic cells;
D O I
10.1191/096032799678840192
中图分类号
R99 [毒物学(毒理学)];
学科分类号
100405 ;
摘要
Cases of karyomegaly were described by Sclare(30) and by Mihatch(31) in patients affected with tubular-interstitial nephropathy. The Karyomegalic cells showed enlarged nuclei with accumulation of genetic material. No aetiology was suggested. Our study of rats experimentally intoxicated by ochratoxin A, a well-known nephrotoxic compound, indicates the presence,of karyomegaly with alteration of the tubular tissue. In control animals no karyomegalic cells were detected. These observations suggest that karyomegaly with megacytosis may be caused by the nephrotoxic ochratoxin A in the kidney. In addition abnormal mitosis together with karyomegalic cells were observed at an earlier stage of the intoxication (30 days) suggesting possible regeneration if the OTA insults are stopped. After 90 days of treatment, the degeneration increased and only karyomegalic and apoptotic-like cells were observed indicating that the regeneration no longer occurs and that the degeneration becomes irreversible.
引用
收藏
页码:410 / 415
页数:6
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