Regulation of Brain-Derived Neurotrophic Factor and Growth Factor Signaling Pathways by Tyrosine Phosphatase Shp2 in the Retina: A Brief Review

被引：23

作者：

Abbasi, Mojdeh ^{[1
]}

Gupta, Vivek ^{[1
]}

Chitranshi, Nitin ^{[1
]}

You, Yuyi ^{[1
,2
]}

Dheer, Yogita ^{[1
]}

Mirzaei, Mehdi ^{[3
,4
]}

Graham, Stuart L. ^{[1
,2
]}

机构：

[1] Macquarie Univ, Fac Med & Hlth Sci, Sydney, NSW, Australia

[2] Univ Sydney, Save Sight Inst, Sydney, NSW, Australia

[3] Macquarie Univ, Australian Proteome Anal Facil, Sydney, NSW, Australia

[4] Macquarie Univ, Dept Mol Sci, Sydney, NSW, Australia

来源：

FRONTIERS IN CELLULAR NEUROSCIENCE | 2018年 / 12卷

基金：

英国医学研究理事会;

关键词：

Shp2; phosphatase; retina; BDNF neurotrophin; growth factors; TrkB receptor; ACTIVATED PROTEIN-KINASE; NOONAN-SYNDROME; GANGLION-CELLS; OCULAR MANIFESTATIONS; PTPN11; MUTATIONS; AMYLOID-BETA; STEM-CELLS; EXPRESSION; FAMILY; DEATH;

D O I：

10.3389/fncel.2018.00085

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

SH2 domain-containing tyrosine phosphatase-2 (PTPN11 or Shp2) is a ubiquitously expressed protein that plays a key regulatory role in cell proliferation, differentiation and growth factor (GF) signaling. This enzyme is well expressed in various retinal neurons and has emerged as an important player in regulating survival signaling networks in the neuronal tissues. The non-receptor phosphatase can translocate to lipid rafts in the membrane and has been implicated to regulate several signaling modules including PI3K/Akt, JAK-STAT and Mitogen Activated Protein Kinase (MAPK) pathways in a wide range of biochemical processes in healthy and diseased states. This review focuses on the roles of Shp2 phosphatase in regulating brain-derived neurotrophic factor (BDNF) neurotrophin signaling pathways and discusses its cross-talk with various GF and downstream signaling pathways in the retina.

引用

页数：10

共 93 条

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