Challenges to Research and Innovation to Optimize Deceased Donor Organ Quality and Quantity

被引：43

作者：

Abt, P. L. ^{[1
]}

Marsh, C. L. ^{[2
,3
]}

Dunn, T. B. ^{[4
]}

Hewitt, W. R. ^{[5
]}

Rodrigue, J. R. ^{[6
,7
]}

Ham, J. M. ^{[8
]}

Feng, S. ^{[9
]}

机构：

[1] Hosp Univ Penn, Dept Surg, Div Transplantat, Philadelphia, PA 19104 USA

[2] Scripps Clin, Scripps Ctr Organ Transplantat, La Jolla, CA 92037 USA

[3] Green Hosp, La Jolla, CA USA

[4] Univ Minnesota, Dept Surg, Div Transplantat, Minneapolis, MN 55455 USA

[5] Mayo Clin, Div Transplant Surg, Phoenix, AZ USA

[6] Beth Israel Deaconess Med Ctr, Dept Psychiat, Ctr Transplant Outcomes & Qual Improvement, Boston, MA 02215 USA

[7] Beth Israel Deaconess Med Ctr, Dept Surg, Ctr Transplant Outcomes & Qual Improvement, Boston, MA 02215 USA

[8] Univ Nevada, Sch Med, Dept Surg, Div Abdominal Organ Transplantat, Las Vegas, NV 89154 USA

[9] Univ Calif San Francisco, Dept Surg, Div Transplantat, San Francisco, CA 94143 USA

来源：

AMERICAN JOURNAL OF TRANSPLANTATION | 2013年 / 13卷 / 06期

关键词：

Consent; deceased donor; donor management research; kidney transplantation; liver transplantation; next-of-kin; RANDOMIZED CONTROLLED-TRIAL; LIVER-TRANSPLANTATION; MANAGEMENT; DEAD; PRESERVATION; DONATION;

D O I：

10.1111/ajt.12243

中图分类号：

R61 [外科手术学];

学科分类号：

100210 [外科学];

摘要：

Solid organ transplantation is encumbered by an increasing number of waitlisted patients unrequited by the current organ supply. Preclinical models suggest that advances in deceased donor management and treatment can increase the quantity and quality of organs available for transplantation. However, the science of donor intervention and the execution of high quality, prospective, multi-center, randomized-controlled trials are restricted by a myriad of logistical challenges mired in regulatory and ethical ambiguity. By highlighting the obstacles to conducting research in deceased donors, this report endeavors to stimulate the creation of a multi-disciplinary framework to facilitate the design, implementation and supervision of innovative trials that increase the quantity and/or quality of deceased donor organs.

引用

页码：1400 / 1404

页数：5

共 13 条

[1]

Review of Randomized Clinical Trials of Donor Management and Organ Preservation in Deceased Donors: Opportunities and Issues [J].

Dikdan, George S. ;

Mora-Esteves, Cesar ;

Koneru, Baburao .

TRANSPLANTATION, 2012, 94 (05) :425-441

[2]

Donor Intervention and Organ Preservation: Where Is the Science and What Are the Obstacles? [J].

Feng, S. .

AMERICAN JOURNAL OF TRANSPLANTATION, 2010, 10 (05) :1155-1162

[3]

The principles of gift law and the regulation of organ donation [J].

Glazier, Alexandra K. .

TRANSPLANT INTERNATIONAL, 2011, 24 (04) :368-372

[4]

Ischemic preconditioning in deceased donor liver transplantation: A prospective randomized clinical trial of safety and efficacy [J].

Koneru, B ;

Fisher, A ;

He, Y ;

Klein, KM ;

Skurnick, J ;

Wilson, DJ ;

de la Torre, AN ;

Merchant, A ;

Arora, R ;

Samanta, AK .

LIVER TRANSPLANTATION, 2005, 11 (02) :196-202

[5]

Methylprednisolone Therapy in Deceased Donors Reduces Inflammation in the Donor Liver and Improves Outcome After Liver Transplantation A Prospective Randomized Controlled Trial [J].

Kotsch, Katja ;

Ulrich, Frank ;

Reutzel-Selke, Anja ;

Pascher, Andreas ;

Faber, W. ;

Warnick, P. ;

Hoffman, S. ;

Francuski, M. ;

Kunert, C. ;

Kuecuek, O. ;

Schumacher, G. ;

Wesslau, C. ;

Lun, A. ;

Kohler, S. ;

Weiss, S. ;

Tullius, S. G. ;

Neuhaus, P. ;

Pratschke, Johann .

ANNALS OF SURGERY, 2008, 248 (06) :1042-1050

[6]

Ethics guidelines for research with the recently dead [J].

Pentz, RD ;

Cohen, CB ;

Wicclair, M ;

DeVita, MA ;

Flamm, AL ;

Youngner, SJ ;

Hamric, AB ;

McCabe, MS ;

Glover, JJ ;

Kittiko, WJ ;

Kinlaw, K ;

Keller, J ;

Asch, A ;

Kavanagh, JJ ;

Arap, W .

NATURE MEDICINE, 2005, 11 (11) :1145-1149

[7]

Eficiency of triiodothyronine treatment on organ donor hemodynamic management and adenine nucleotide concentration [J].

Pérez-Blanco, A ;

Caturla-Such, J ;

Cánovas-Robles, J ;

Sanchez-Payá, J .

INTENSIVE CARE MEDICINE, 2005, 31 (07) :943-948

[8]

Informed consent in research to improve the number and quality of deceased donor organs [J].

Rey, Michael M. ;

Ware, Lorraine B. ;

Matthay, Michael A. ;

Bernard, Gordon R. ;

McGuire, Amy L. ;

Caplan, Arthur L. ;

Halpern, Scott D. .

CRITICAL CARE MEDICINE, 2011, 39 (02) :280-283

[9]

Effects of Donor Pretreatment With Dopamine on Graft Function After Kidney Transplantation A Randomized Controlled Trial [J].

Schnuelle, Peter ;

Gottmann, Uwe ;

Hoeger, Simone ;

Boesebeck, Detlef ;

Lauchart, Werner ;

Weiss, Christel ;

Fischereder, Michael ;

Jauch, Karl-Walter ;

Heemann, Uwe ;

Zeier, Martin ;

Hugo, Christian ;

Pisarski, Przemyslaw ;

Kraemer, Bernhard K. ;

Lopau, Kai ;

Rahmel, Axel ;

Benck, Urs ;

Birck, Rainer ;

Yard, Benito Antonio .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2009, 302 (10) :1067-1075

[10]

Organ donation and utilization in the United States, 1997-2006 [J].

Sung, R. S. ;

Galloway, J. ;

Tuttle-Newhall, J. E. ;

Mone, T. ;

Laeng, R. ;

Freise, C. E. ;

Rao, P. S. .

AMERICAN JOURNAL OF TRANSPLANTATION, 2008, 8 (04) :922-934

← 1 2 →