Whither goest the RGS proteins?

被引：99

作者：

Siderovski, DP ^{[1
]}

Strockbine, B ^{[1
]}

Behe, CI ^{[1
]}

机构：

[1] Univ N Carolina, Sch Med, Dept Pharmacol, Chapel Hill, NC 27599 USA

来源：

CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY | 1999年 / 34卷 / 04期

关键词：

desensitization; effector proteins; GGL; GoLoco; PDZ; PTB; regulators of G protein signaling; RGS; scaffold proteins; signal transduction;

D O I：

10.1080/10409239991209273

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Studies of the desensitization of G protein-coupled signal transduction have led to the discovery of a family of guanosine triphosphatase-activating proteins (GAPs) for heterotrimeric G protein alpha subunits - the "regulator of G protein signaling" or RGS proteins. In considering both documented and potential functions of several RGS protein family members with demonstrable multidomain compositions (p115RhoGEF, PDZRhoGEF, Axin, Axil/Conductin, D-AKAP2, the G protein-coupled receptor kinases [GRKs], the DEP/GGL/RGS subfamily [RGS6, RGS7, RGS9, RGS11], and RGS12), this review explores the shift in our appreciation of the RGS proteins from unidimensional desensitizing agents to multifocal signal transduction regulators.

引用

页码：215 / 251

页数：37

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